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Surgical Management of Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma Associated With Light-Chain Deposition Disease  Juan A. Muñoz-Largacha, MD,

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Presentation on theme: "Surgical Management of Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma Associated With Light-Chain Deposition Disease  Juan A. Muñoz-Largacha, MD,"— Presentation transcript:

1 Surgical Management of Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma Associated With Light-Chain Deposition Disease  Juan A. Muñoz-Largacha, MD, Carl J. O’Hara, MD, J. Mark Sloan, MD, Hiran C. Fernando, MD, Virginia R. Litle, MD  The Annals of Thoracic Surgery  Volume 101, Issue 6, Pages e207-e210 (June 2016) DOI: /j.athoracsur Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Computed tomography of the chest showing right middle lobe (RML) nodule (arrow). The Annals of Thoracic Surgery  , e207-e210DOI: ( /j.athoracsur ) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 (A) Interface between intraalveolar deposits and normal lung (hematoxylin and eosin; ×40). (B) Eosinophilic deposits associated with patchy infiltrates of small lymphoid aggregates (hematoxylin and eosin; ×60). (C) Lymphoid aggregates are positive for the B-cell antigen CD20 (immunohistochemical staining, ×200). (D) Immunohistochemical staining for CD138 plasma-cell antigen shows clustered plasma cells admixed with lymphoid aggregates (×250). The Annals of Thoracic Surgery  , e207-e210DOI: ( /j.athoracsur ) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 In situ hybridization stain for light-chain immunoglobulins showing clonal restriction for (A) kappa versus (B) lambda light chains (×150). The Annals of Thoracic Surgery  , e207-e210DOI: ( /j.athoracsur ) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 (A) Immunohistochemical staining showing kappa light-chain staining of eosinophilic deposits (light brown) versus (B) lambda light-chain staining (×250). The Annals of Thoracic Surgery  , e207-e210DOI: ( /j.athoracsur ) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

6 Fig 5 Electron microscopy (EM) showing amorphous granular deposits (black) (×12,000). The Annals of Thoracic Surgery  , e207-e210DOI: ( /j.athoracsur ) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

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