1. Combined data from RISC (n=3,024) and San Raffaele dataset (n=1,067)
Supplementary Figure 1
Study flow chart, with reasons and counts for patient exclusions. RC = radical cystectomy; RISC = Retrospective International Study of Invasive/Advanced Cancer of the Urothelium;
UC = urothelial carcinoma.
Combined data from RISC (n=3,024) and San Raffaele dataset (n=1,067)
n=1,480 excluded for clinical N1-3 stage, and 851 for clinical M1 stage
n=132 upper-tract or urethral primary tumor
n=434 did not undergo RC
n=1,194 selected patients
n=78 with predominant non-UC histology
n=166 missing key survival data
n=950 patients in the final data analyses