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Volume 49, Issue 5, Pages (March 2006)

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1 Volume 49, Issue 5, Pages 642-644 (March 2006)
Policing the Ball: A New Potassium Channel Subunit Determines Inactivation Rate  Leonard K. Kaczmarek  Neuron  Volume 49, Issue 5, Pages (March 2006) DOI: /j.neuron Copyright © 2006 Elsevier Inc. Terms and Conditions

2 Figure 1 Lgi1 Prevents Inactivation by the Kvβ1 Subunit of Kv1.1 Channels (A) The cytoplasmic N terminus of potassium channel α subunits such as the Drosophila Shaker channel and the mammalian Kv1.4 channel contains a “ball and chain” region, which, shortly after on depolarization of the channel, allows the ball to occlude the mouth of the channel, producing rapid channel inactivation. (B) For Kv1.1 channels, the ball and chain can be provided by the Kvβ1 subunit. (C) Binding of Lgi1 to Kv1.1 prevents access of Kvβ1 to the pore of the channel, preventing inactivation. (D) “Bottom up” view of a tetrameric channel with two Kv1.1 and two Kv1.4 channel subunits. Lgi1 prevents access of Kvβ1 to the central pore of the channel complex but does not affect the movement of the N-terminal inactivation ball of Kv1.4. The slower inactivation of these channels is regulated solely by the intrinsic inactivation of Kv1.4 subunits. Neuron  , DOI: ( /j.neuron ) Copyright © 2006 Elsevier Inc. Terms and Conditions

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