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Evidence That the Penetrance of Mutations at the RP11 Locus Causing Dominant Retinitis Pigmentosa Is Influenced by a Gene Linked to the Homologous RP11.

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Presentation on theme: "Evidence That the Penetrance of Mutations at the RP11 Locus Causing Dominant Retinitis Pigmentosa Is Influenced by a Gene Linked to the Homologous RP11."— Presentation transcript:

1 Evidence That the Penetrance of Mutations at the RP11 Locus Causing Dominant Retinitis Pigmentosa Is Influenced by a Gene Linked to the Homologous RP11 Allele  T.L. McGee, M. Devoto, J. Ott, E.L. Berson, T.P. Dryja  The American Journal of Human Genetics  Volume 61, Issue 5, Pages (November 1997) DOI: /301614 Copyright © 1997 The American Society of Human Genetics Terms and Conditions

2 Figure 1 Schematic pedigrees of three families (1295, 2474, and 1562) with dominant reduced-penetrance RP. Blackened symbols indicate affected individuals. The alleles at microsatellite loci D19S180, D19S572, and D19S926 are listed (from top to bottom, respectively) below the symbols for the individuals who donated blood samples for this research. Each family has a different cosegregating haplotype. The American Journal of Human Genetics  , DOI: ( /301614) Copyright © 1997 The American Society of Human Genetics Terms and Conditions

3 Figure 2 Plot of multipoint LOD scores as a function of genetic distance from locus D19S180. The LOD scores were summed from data from the three families in this study. The American Journal of Human Genetics  , DOI: ( /301614) Copyright © 1997 The American Society of Human Genetics Terms and Conditions

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