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Dynamic Encoding in the Notch Pathway

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Presentation on theme: "Dynamic Encoding in the Notch Pathway"— Presentation transcript:

1 Dynamic Encoding in the Notch Pathway
Sean G. Megason  Developmental Cell  Volume 44, Issue 4, Pages (February 2018) DOI: /j.devcel Copyright © 2018 Elsevier Inc. Terms and Conditions

2 Figure 1 Different Signals through the Same Receptor
Delta1 binds Notch1 to cause pulses of NICD release, with a higher pulse frequency corresponding to a stronger signal. Delta4 binds Notch1 to trigger sustained NICD release, with different amplitudes for different strength signals. These pulsed versus sustained NICD dynamics upregulate different targets: Hes1 for Delta1, and Hey1 and HeyL for Delta4. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2018 Elsevier Inc. Terms and Conditions

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