1. Crossing the Exon Molecular Cell
Alberto Moldón, Charles Query 
Molecular Cell 
Volume 38, Issue 2, Pages (April 2010)
DOI: /j.molcel
Copyright © 2010 Elsevier Inc. Terms and Conditions

2. Figure 1 Schematic Pathway of Exon-Defined Spliceosome Assembly
(1) U2 snRNP binds upstream of the exon at the BS, and U1 snRNP binds to the downstream 5′SS; SR proteins bound to ESE stabilize the cross-exon A-like complex. (2) The U4/U6-U5 tri-snRNP binds the complex, forming the cross-exon B-like complex. (3) U6 interacts with the upstream 5′SS, allowing a switch from the cross-exon to the cross-intron structure. (4) Conformational rearrangements (release of U1 and U4) lead to formation of activated B∗ complex. (5) Catalytic steps of the reaction and release of products. Double-headed black arrows denote interactions. SS, splice site; BS, branch site; ESE, exonic splicing enhancer.
Molecular Cell  , DOI: ( /j.molcel )
Copyright © 2010 Elsevier Inc. Terms and Conditions