1. Volume 15, Issue 4, Pages 830-842 (April 2016)
A Polymorphic Antioxidant Response Element Links NRF2/sMAF Binding to Enhanced MAPT Expression and Reduced Risk of Parkinsonian Disorders 
Xuting Wang, Michelle R. Campbell, Sarah E. Lacher, Hye-Youn Cho, Ma Wan, Christopher L. Crowl, Brian N. Chorley, Gareth L. Bond, Steven R. Kleeberger, Matthew Slattery, Douglas A. Bell 
Cell Reports 
Volume 15, Issue 4, Pages (April 2016)
DOI: /j.celrep
Copyright © 2016 The Authors Terms and Conditions

2. Cell Reports 2016 15, 830-842DOI: (10.1016/j.celrep.2016.03.068)
Copyright © 2016 The Authors Terms and Conditions

3. Figure 1 Study Design and Summary of Candidates
(A) Overview of workflow for identifying functional ARE SNPs associated with disease.
(B) The significance of GWAS SNPs linked to ARE SNPs.
Cell Reports  , DOI: ( /j.celrep )
Copyright © 2016 The Authors Terms and Conditions

4. Figure 2 Characteristics of rs242561
(A) Location relative to risk SNP for PSP and PD and ChIP-seq signals.
(B) Position in ARE motif.
(C) Conservation.
(D) Allele-specific binding.
(E) Allele-specific transactivation.
(F) RT-PCR of MAPT levels in human IMR32 neuroblastoma cells treated with t-BHQ or vehicle.
(G) Nrf2 +/+ and Nrf2 −/− mice were exposed to oxidative stress induced by hyperoxia, and Mapt gene expression level was measured in mRNA from cerebellum by RT-PCR.
See also Figure S3 and Tables S4 and S5.
Cell Reports  , DOI: ( /j.celrep )
Copyright © 2016 The Authors Terms and Conditions

5. Figure 3
Association of rs Genotypes with MAPT mRNA Levels in Humans
(A) Map of rs and eQTL SNPs with LD correlations (R2) within the MAPT gene.
(B) MAPT mRNA levels and genotypes of rs in human brain TCTX as measured by Affymetrix Exon array (UKBEC). TT is the stronger binding genotype.
See also Figure S3.
Cell Reports  , DOI: ( /j.celrep )
Copyright © 2016 The Authors Terms and Conditions