1. Spread of an Inactive Form of Caspase-12 in Humans Is Due to Recent Positive Selection 
Yali Xue, Allan Daly, Bryndis Yngvadottir, Mengning Liu, Graham Coop, Yuseob Kim, Pardis Sabeti, Yuan Chen, Jim Stalker, Elizabeth Huckle, John Burton, Steven Leonard, Jane Rogers, Chris Tyler-Smith 
The American Journal of Human Genetics 
Volume 78, Issue 4, Pages (April 2006)
DOI: /503116
Copyright © 2006 The American Society of Human Genetics Terms and Conditions

2. Figure 1
Worldwide distribution of the active and inactive forms of the caspase-12 gene in the HGDP-CEPH diversity panel. Circle area is proportional to sample size, up to a maximum of 50 individuals.
The American Journal of Human Genetics  , DOI: ( /503116)
Copyright © 2006 The American Society of Human Genetics Terms and Conditions

3. Figure 2
Structure of the caspase-12 gene. The exon-intron structure—including exon 3, which is present only in some transcripts—is shown at the top, as is the whole sequenced region and the location of the 8.6-kb LD block. The lower part of the figure shows the LD block identified using Haploview. Each square represents a pairwise value of D′, with the standard color coding (red indicates LOD⩾2 and D′=1; pink indicates LOD⩾2 and D′<1; blue indicates LOD<2 and D′=1; white indicates LOD<2 and D′<1).
The American Journal of Human Genetics  , DOI: ( /503116)
Copyright © 2006 The American Society of Human Genetics Terms and Conditions

4. Figure 3
Inferred caspase-12 haplotypes. Only positions that are variable in humans are shown, coded according to whether they carry the same allele as chimpanzee (white) or not (yellow), except that the stop-codon polymorphism is shown in blue or red, respectively. The low diversity and high frequency of derived alleles can be seen in the inactive genes.
The American Journal of Human Genetics  , DOI: ( /503116)
Copyright © 2006 The American Society of Human Genetics Terms and Conditions

5. Figure 4
Median-joining network of inferred caspase-12 haplotypes from the 8.6-kb LD block. Roots 1, 2, and 3 are discussed in the text. Circle area is proportional to haplotype frequency, and circles are coded according to population.
The American Journal of Human Genetics  , DOI: ( /503116)
Copyright © 2006 The American Society of Human Genetics Terms and Conditions

6. Figure 5
Top, EHH as a function of genetic distance in the CEU. Bottom, Corresponding haplotype bifurcation diagram.
The American Journal of Human Genetics  , DOI: ( /503116)
Copyright © 2006 The American Society of Human Genetics Terms and Conditions

7. Figure 6 Likelihood surface for the selection parameter 4Nes
The American Journal of Human Genetics  , DOI: ( /503116)
Copyright © 2006 The American Society of Human Genetics Terms and Conditions