1. Positron emission tomography study of regional cerebral blood flow and flow– metabolism coupling during general anaesthesia with xenon in humans†  
S. Rex, P.T. Meyer, J.-H. Baumert, R. Rossaint, M. Fries, U. Büll, W.M. Schaefer 
British Journal of Anaesthesia 
Volume 100, Issue 5, Pages (May 2008)
DOI: /bja/aen036
Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

2. Fig 1
Effects of xenon on CBF as assessed by the PI (for further details, see text). PI (in kcnt ml−1MBq−1) is colour-coded as indicated by the colour bar located on the left side of each panel. The upper row shows the group mean parametric PI image of the awake state, whereas the lower row depicts the group mean parametric PI image during general anaesthesia with one MAC xenon. Group mean parametric PI images were calculated using the stereotactically normalized individual integral PET images of all subjects.
British Journal of Anaesthesia  , DOI: ( /bja/aen036)
Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

3. Fig 2
(a) Effects of general anaesthesia with one MAC xenon on CBF, as assessed by the PI in a volumes of interest-based analysis. Statistical probabilities of paired comparisons (xenons vs awake state) are indicated for thalamus and centrum semiovale (regions with greatest change). (b) Relative changes (in % from awake) of regional cerebral metabolic rate of glucose (CMRglc) and PI induced by general anaesthesia with one MAC xenon. *, **P<0.05 (0.01): Δ CMRglc vs Δ PI.
British Journal of Anaesthesia  , DOI: ( /bja/aen036)
Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

4. Fig 3
Association between mean rCBF (assessed with the PI) and mean regional cerebral glucose metabolism [CMRglc] during wakefulness and anaesthesia with one MAC xenon. For each of the 13 studied brain areas, the group mean of regional PI is plotted against the group mean of CMRglc. The regression slopes [awake (dashed line)=0.3192; xenon (solid line)=0.4061] were not significantly different, as indicated by ancova (for further details, see text).
British Journal of Anaesthesia  , DOI: ( /bja/aen036)
Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

5. Fig 4
Cerebral regions with xenon-induced relative increases in rCBF as assessed by voxel-based statistical analysis with SPM2. General anaesthesia with one MAC xenon was compared with the awake state. (a) SPM glass brain illustration (top: right lateral view, bottom: back to front view). Voxel darkness increases with increasing t-value. The t-map was thresholded at t=6.54 (i.e. P<0.05, corrected for multiple comparisons). (b) Overlay of the SPM t-map onto sagittal, coronal, and transversal sections of the SPM T1 magnetic resonance imaging template illustrating the areas of relative CBF increase within the white matter. Areas of CBF increase are colour-coded in dependency of statistical significance. For better illustration of the results, the t-map was thresholded at t=3.50 (i.e. P<0.001, uncorrected for multiple comparisons).
British Journal of Anaesthesia  , DOI: ( /bja/aen036)
Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

6. Fig 5
Cerebral regions with xenon-induced relative decreases in rCBF as assessed by voxel-based statistical analysis with SPM2. General anaesthesia with one MAC xenon was compared with the awake state. (a) SPM glass brain illustration (top: right lateral view, middle: back to front view, bottom: top to bottom view). Voxel darkness increases with increasing t-value. (b) Overlay of the t-map onto sagittal, transversal, and coronal sections of the SPM T1 magnetic resonance imaging template illustrating the areas of relative CBF decreases within the grey matter (a: 1, posterior cingulate gyrus; 2, anterior cingulate gyrus; 3, thalamus; 4, orbito- and mesiofrontal cortex); b, cerebellum; c, thalamus (arrow); d, right hippocampus; e, left hippocampus). Areas of relative CBF decreases are colour-coded in dependency of statistical significance. For both illustrations, the t-map was thresholded at t=6.54 (i.e. P<0.05, corrected for multiple comparisons).
British Journal of Anaesthesia  , DOI: ( /bja/aen036)
Copyright © 2008 British Journal of Anaesthesia Terms and Conditions