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Insulin-like growth factor-II (IGF-II), IGF-binding protein-3 (IGFBP-3), and IGFBP-4 in follicular fluid are associated with oocyte maturation and embryo.

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Presentation on theme: "Insulin-like growth factor-II (IGF-II), IGF-binding protein-3 (IGFBP-3), and IGFBP-4 in follicular fluid are associated with oocyte maturation and embryo."— Presentation transcript:

1 Insulin-like growth factor-II (IGF-II), IGF-binding protein-3 (IGFBP-3), and IGFBP-4 in follicular fluid are associated with oocyte maturation and embryo development  Tzu-Hao Wang, M.D., Ph.D., Chia-Lin Chang, M.D., Hsien-Ming Wu, M.D., Ya-Ming Chiu, M.Sc., Chun-Kai Chen, M.D., Hsin-Shih Wang, M.D., Ph.D.  Fertility and Sterility  Volume 86, Issue 5, Pages (November 2006) DOI: /j.fertnstert Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

2 FIGURE 1 The correlation between embryo score on day 3 (72 hours after oocyte retrieval) and levels of IGFs and IGFBPs in follicular fluid (n = 120): (A) IGF-II, (B) IGFBP-3, (C) IGFBP-4, and (D) PAPP-A. d.f. = degree of freedom. Wang. IGFs/IGFBPs and embryo development. Fertil Steril 2006. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

3 FIGURE 2 The relationship between FF levels of (A) IGF-II and IGFBP-4, and (B) PAPP-A and IGFBP-4, analyzed by linear regression (n = 120). d.f. = degree of freedom. Wang. IGFs/IGFBPs and embryo development. Fertil Steril 2006. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

4 FIGURE 3 Western blot analysis of pooled FF collected from follicles where oocytes were fertilized and developed into embryos using anti-IGFBP-4 (left) and anti-β-actin (right) antibodies. Lane 1, embryo score on day 2 (48 hours after oocyte retrieval) ≥8, representing good embryo development; lane 2, embryo score on day 2 ≤2, indicating an arrest of embryo development. Shown herein is a representative figure from three independent experiments with similar results. Wang. IGFs/IGFBPs and embryo development. Fertil Steril 2006. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

5 FIGURE 4 Stimulation of P secretion from pooled granulosa cells by in vitro treatment with recombinant IGF-II, IGFBP-3, IGFBP-4, or indicated combinations for 24 hours. Data shown are means ± SD from three independent experiments. Progesterone secretion in each treatment is normalized with the cell number. Abbreviations: II = IGF-II, 3 = IGFBP-3, 4 = IGFBP-4. *P=.013. Wang. IGFs/IGFBPs and embryo development. Fertil Steril 2006. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

6 FIGURE 5 The effect of the FF levels of IGFs (IGF-I and IGF-II), IGFBPs (IGFBP-1, IGFBP-3, and IGFBP-4), and PAPP-A on the outcomes of oocyte fertilization and subsequent embryo development. Wang. IGFs/IGFBPs and embryo development. Fertil Steril 2006. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

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