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Manasvi Jaitly, MBBS, MS, Sumit Mohan, MBBS, MPH, Constance M

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Presentation on theme: "Manasvi Jaitly, MBBS, MS, Sumit Mohan, MBBS, MPH, Constance M"— Presentation transcript:

1 Hypokalemia During Sickle Cell Crises Apparently Due to Intermittent Mineralocorticoid Excess 
Manasvi Jaitly, MBBS, MS, Sumit Mohan, MBBS, MPH, Constance M. Park, MD, PhD, Herman L. Anderson, MD, Jen-Tse Cheng, MD, Velvie A. Pogue, MD  American Journal of Kidney Diseases  Volume 51, Issue 2, Pages (February 2008) DOI: /j.ajkd Copyright © 2008 National Kidney Foundation, Inc. Terms and Conditions

2 Figure 1 Time course of sickle cell crises shows reciprocal relationship of serum potassium and serum bilirubin levels. To convert bilirubin in mg/dL to μmol/L, multiply by 17.1; serum potassium in mmol/L and mEq/L is equivalent. American Journal of Kidney Diseases  , DOI: ( /j.ajkd ) Copyright © 2008 National Kidney Foundation, Inc. Terms and Conditions

3 Figure 2 Relationship between serum potassium and serum bilirubin: y = 4.3 − 0.03x; r = 0.75; P < To convert bilirubin in mg/dL to μmol/L, multiply by 17.1. American Journal of Kidney Diseases  , DOI: ( /j.ajkd ) Copyright © 2008 National Kidney Foundation, Inc. Terms and Conditions

4 Figure 3 Relationship between fractional excretion of potassium (FEK) and serum bilirubin level: y = x; r = 0.63; P < Relationship between transtubular potassium gradient (TTKG) and serum bilirubin level: y = x; r = 0.48; P = To convert bilirubin in mg/dL to μmol/L, multiply by 17.1. American Journal of Kidney Diseases  , DOI: ( /j.ajkd ) Copyright © 2008 National Kidney Foundation, Inc. Terms and Conditions


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