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Osteoarthritis year in review 2017: genetics and epigenetics

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1 Osteoarthritis year in review 2017: genetics and epigenetics
M.J. Peffers, P. Balaskas, A. Smagul  Osteoarthritis and Cartilage  Volume 26, Issue 3, Pages (March 2018) DOI: /j.joca Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

2 Fig. 1 LncRNA studies in OA targeting different mechanisms of action of lncRNAs. Three functions of lncRNAs have been investigated; through acting as sponges for miRs, transcriptional activation and repression and the regulation of the chromatin state (TMSB4; thymosin-β4, SMSCs; synovium-derived MSCs, MMP; metalloproteinase). References; 1. Zhang et al., , 2. Liu et al., , 3. Zhang et al., , 4. Zhang et al., Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

3 Fig. 2 Schematic diagram of a systems orientated approach to develop novel diagnostic and treatment solutions to OA. Omics studies enable pictures of the biological hierarchy. Red boxes highlight the areas covered in this review67. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions


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