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Biologic degeneration of vein grafts after thrombotic occlusion: thrombectomy within 3 days results in better indices of viability  Shigehisa Kawai, MD,

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Presentation on theme: "Biologic degeneration of vein grafts after thrombotic occlusion: thrombectomy within 3 days results in better indices of viability  Shigehisa Kawai, MD,"— Presentation transcript:

1 Biologic degeneration of vein grafts after thrombotic occlusion: thrombectomy within 3 days results in better indices of viability  Shigehisa Kawai, MD, Tadahiro Sasajima, MD, Keisuke Satoh, MD, Masashi Inaba, MD, Nobuyoshi Azuma, MD, Kosuke Yamazaki, MD, Kensuke Oikawa, MD  Journal of Vascular Surgery  Volume 38, Issue 2, Pages (August 2003) DOI: /S (03)

2 Fig 1 Immunohistochemistry for macrophages in thrombosed grafts. Note moderate infiltration of macrophages (arrows) both inside and outside of 3-day grafts. (Mouse anti-human CD68 staining method; original magnification, ×30.) Journal of Vascular Surgery  , DOI: ( /S (03) )

3 Fig 2 Immunohistochemistry results for α-actin positive cells in thrombosed grafts. A, Three-day graft shows no significant decrease in positive cell area when compared with control graft. B, Note obvious decrease in positive cell area in 5-day graft. Journal of Vascular Surgery  , DOI: ( /S (03) )

4 Fig 3 Immunohistochemistry results for proliferating cell nuclear antigen (PCNA)–positive cells (arrows) in thrombosed grafts. A, Control graft. B, Note significant increase in PCNA-positive cells in 3-day graft. C, There is obvious decrease in PCNA cells in 5-day graft. (PCNA staining method; original magnification, ×60.) Continued. Journal of Vascular Surgery  , DOI: ( /S (03) )

5 Fig 3 Immunohistochemistry results for proliferating cell nuclear antigen (PCNA)–positive cells (arrows) in thrombosed grafts. A, Control graft. B, Note significant increase in PCNA-positive cells in 3-day graft. C, There is obvious decrease in PCNA cells in 5-day graft. (PCNA staining method; original magnification, ×60.) Continued. Journal of Vascular Surgery  , DOI: ( /S (03) )

6 Fig 4 Immunohistochemistry results for apoptotic cells in 3-day grafts. There are no significant changes in apoptotic cell numbers (arrows) between control grafts (A), 3-day grafts (B), or 5-day grafts (C). (ssDNA staining method; original magnification, ×60.) Continued. Journal of Vascular Surgery  , DOI: ( /S (03) )

7 Fig 4 Immunohistochemistry results for apoptotic cells in 3-day grafts. There are no significant changes in apoptotic cell numbers (arrows) between control grafts (A), 3-day grafts (B), or 5-day grafts (C). (ssDNA staining method; original magnification, ×60.) Continued. Journal of Vascular Surgery  , DOI: ( /S (03) )

8 Fig 5 Scanning electron micrograph of luminal surface of salvaged graft 28 days after thrombectomy reveals a tight endothelial cell lining. (Original magnification, ×1000.) Journal of Vascular Surgery  , DOI: ( /S (03) )

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