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Differential diagnosis of thymic carcinoma and lung carcinoma with the use of antibodies to cytokeratins  Ichiro Fukai, MDa, Akira Masaoka, MD, PhDa,

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Presentation on theme: "Differential diagnosis of thymic carcinoma and lung carcinoma with the use of antibodies to cytokeratins  Ichiro Fukai, MDa, Akira Masaoka, MD, PhDa,"— Presentation transcript:

1 Differential diagnosis of thymic carcinoma and lung carcinoma with the use of antibodies to cytokeratins  Ichiro Fukai, MDa, Akira Masaoka, MD, PhDa, Takahiko Hashimoto, MDa, Yosuke Yamakawa, MDa, Hiroshi Niwa, MDa, Masanobu Kiriyama, MDa, Tadaaki Eimoto, MD, PhDb  The Journal of Thoracic and Cardiovascular Surgery  Volume 110, Issue 6, Pages (December 1995) DOI: /S (95) Copyright © 1995 Mosby, Inc. Terms and Conditions

2 Fig. 1 Double immunolabeling of normal human thymus tissue with RCK105 and 2D7 (mirror sections). A, RCK105 (original magnification ×20). B, 2D7 (original magnification ×20). RCK105 labeled somewhat smaller number of medullary epithelial cells than 2D7. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

3 Fig. 1 Double immunolabeling of normal human thymus tissue with RCK105 and 2D7 (mirror sections). A, RCK105 (original magnification ×20). B, 2D7 (original magnification ×20). RCK105 labeled somewhat smaller number of medullary epithelial cells than 2D7. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

4 Fig. 2 Hematoxylin and eosin-stained sections of thymic keratinizing SCC (A) and pulmonary keratinizing SCC (B) (original magnification ×80). Cytokeratin 7 antibody RCK105 shows completely positive reaction in thymic keratinizing SCC (C), but does not react with pulmonary keratinizing SCC (D) (original magnification ×80). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

5 Fig. 2 Hematoxylin and eosin-stained sections of thymic keratinizing SCC (A) and pulmonary keratinizing SCC (B) (original magnification ×80). Cytokeratin 7 antibody RCK105 shows completely positive reaction in thymic keratinizing SCC (C), but does not react with pulmonary keratinizing SCC (D) (original magnification ×80). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

6 Fig. 2 Hematoxylin and eosin-stained sections of thymic keratinizing SCC (A) and pulmonary keratinizing SCC (B) (original magnification ×80). Cytokeratin 7 antibody RCK105 shows completely positive reaction in thymic keratinizing SCC (C), but does not react with pulmonary keratinizing SCC (D) (original magnification ×80). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

7 Fig. 2 Hematoxylin and eosin-stained sections of thymic keratinizing SCC (A) and pulmonary keratinizing SCC (B) (original magnification ×80). Cytokeratin 7 antibody RCK105 shows completely positive reaction in thymic keratinizing SCC (C), but does not react with pulmonary keratinizing SCC (D) (original magnification ×80). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

8 Fig. 3 A, Hematoxylin and eosin-stained section of lymphoepithelioma-like thymic carcinoma (original magnification ×80). B, Large areas of this tumor are stained with cytokeratin 13 antibody 2D7 (original magnification ×80). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

9 Fig. 3 A, Hematoxylin and eosin-stained section of lymphoepithelioma-like thymic carcinoma (original magnification ×80). B, Large areas of this tumor are stained with cytokeratin 13 antibody 2D7 (original magnification ×80). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions


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