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Direct effect of morphine on breast cancer cell function in vitro: role of the NET1 gene
P. Ecimovic, D. Murray, P. Doran, J. McDonald, D.G. Lambert, D.J. Buggy British Journal of Anaesthesia Volume 107, Issue 6, Pages (December 2011) DOI: /bja/aer259 Copyright © 2011 The Author(s) Terms and Conditions
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Fig 1 Proliferation of breast cancer cells after incubation with morphine or DMSO control. Proliferation of (a) MCF7 cells and (b) MDA-MB-231 cells. Median value (n=3) is shown. (c) Difference between morphine and control. *P<0.05 compared with control. British Journal of Anaesthesia , DOI: ( /bja/aer259) Copyright © 2011 The Author(s) Terms and Conditions
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Fig 2 Migration of breast cancer cells after incubation with morphine or DMSO control. Migration of (a) MCF7 cells and (b) MDA-MB-231 cells. Median value (n=3) is shown. (c) Difference between morphine and control. *P<0.05 compared with control. British Journal of Anaesthesia , DOI: ( /bja/aer259) Copyright © 2011 The Author(s) Terms and Conditions
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Fig 3 Fold change of NET1 expression after incubation of cells with morphine. NET1 expression in (a) MCF7 cells and (b) MDA-MB-231 cells. All values are statistically significant (P<0.05). Individual raw data points are shown. British Journal of Anaesthesia , DOI: ( /bja/aer259) Copyright © 2011 The Author(s) Terms and Conditions
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Fig 4 Migration of breast cancer cells with silenced NET1 gene after incubation with morphine or DMSO control. Migration of (a) MCF7 cells and (b) MDA-MB-231 cells. Median value (n=3) is shown. *P<0.05 compared with control. British Journal of Anaesthesia , DOI: ( /bja/aer259) Copyright © 2011 The Author(s) Terms and Conditions
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