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Role of Niacin in Current Clinical Practice: A Systematic Review

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Presentation on theme: "Role of Niacin in Current Clinical Practice: A Systematic Review"— Presentation transcript:

1 Role of Niacin in Current Clinical Practice: A Systematic Review
Aakash Garg, MD, Abhishek Sharma, MD, Parasuram Krishnamoorthy, MD, Jalaj Garg, MD, Deepti Virmani, MD, Toishi Sharma, MD, Giulio Stefanini, MD, John B. Kostis, MD, Debabrata Mukherjee, MD, MS, Ekaterina Sikorskaya, MD  The American Journal of Medicine  Volume 130, Issue 2, Pages (February 2017) DOI: /j.amjmed Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 The PRISMA flow chart for the trial selection process.
The American Journal of Medicine  , DOI: ( /j.amjmed ) Copyright © 2016 Elsevier Inc. Terms and Conditions

3 Figure 2 Forest plot showing effect of niacin on risk of all-cause mortality. CI = confidence interval; RR = risk ratio. For full trial names, see Table 1 footnote. The American Journal of Medicine  , DOI: ( /j.amjmed ) Copyright © 2016 Elsevier Inc. Terms and Conditions

4 Figure 3 Forest plot showing effect of niacin on risk of cardiovascular (CV) mortality. CI = confidence interval; RR = risk ratio. For full trial names, see Table 1 footnote. The American Journal of Medicine  , DOI: ( /j.amjmed ) Copyright © 2016 Elsevier Inc. Terms and Conditions

5 Figure 4 Forest plot showing effect of niacin on coronary death. CI = confidence interval; RR = risk ratio. For full trial names, see Table 1 footnote. The American Journal of Medicine  , DOI: ( /j.amjmed ) Copyright © 2016 Elsevier Inc. Terms and Conditions

6 Figure 5 Forest plot showing effect of niacin on myocardial infarction (MI). CI = confidence interval; RR = risk ratio. For full trial names, see Table 1 footnote. The American Journal of Medicine  , DOI: ( /j.amjmed ) Copyright © 2016 Elsevier Inc. Terms and Conditions

7 Figure 6 Forest plot showing effect of niacin on revascularization rates. CI = confidence interval; RR = risk ratio. For full trial names, see Table 1 footnote. The American Journal of Medicine  , DOI: ( /j.amjmed ) Copyright © 2016 Elsevier Inc. Terms and Conditions

8 Figure 7 Forest plot showing effect of niacin on stroke. CI = confidence interval; RR = risk ratio. For full trial names, see Table 1 footnote. The American Journal of Medicine  , DOI: ( /j.amjmed ) Copyright © 2016 Elsevier Inc. Terms and Conditions

9 Figure 8 Forest plot showing effect of niacin on new-onset or worse control of pre-existing diabetes mellitus (DM). CI = confidence interval; M-H = Mantel-Haenszel. For full trial names, see Table 1 footnote. The American Journal of Medicine  , DOI: ( /j.amjmed ) Copyright © 2016 Elsevier Inc. Terms and Conditions

10 Figure 9 Forest plot showing effect of niacin on gastrointestinal (GI) adverse events. CI = confidence interval; M-H = Mantel-Haenszel. For full trial names, see Table 1 footnote. The American Journal of Medicine  , DOI: ( /j.amjmed ) Copyright © 2016 Elsevier Inc. Terms and Conditions

11 Figure 10 Forest plot showing effect of niacin on musculoskeletal adverse events. CI = confidence interval; M-H = Mantel-Haenszel. For full trial names, see Table 1 footnote. The American Journal of Medicine  , DOI: ( /j.amjmed ) Copyright © 2016 Elsevier Inc. Terms and Conditions

12 Figure 11 Forest plot showing effect of niacin on skin flushing. CI = confidence interval; M-H = Mantel-Haenszel. For full trial names, see Table 1 footnote. The American Journal of Medicine  , DOI: ( /j.amjmed ) Copyright © 2016 Elsevier Inc. Terms and Conditions

13 Figure 12 Forest plot showing effect of niacin on liver toxicity. CI = confidence interval; M-H = Mantel-Haenszel. For full trial names, see Table 1 footnote. The American Journal of Medicine  , DOI: ( /j.amjmed ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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