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Effect of pain on autonomic nervous system indices derived from photoplethysmography in healthy volunteers  K. Hamunen, V. Kontinen, E. Hakala, P. Talke,

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Presentation on theme: "Effect of pain on autonomic nervous system indices derived from photoplethysmography in healthy volunteers  K. Hamunen, V. Kontinen, E. Hakala, P. Talke,"— Presentation transcript:

1 Effect of pain on autonomic nervous system indices derived from photoplethysmography in healthy volunteers  K. Hamunen, V. Kontinen, E. Hakala, P. Talke, M. Paloheimo, E. Kalso  British Journal of Anaesthesia  Volume 108, Issue 5, Pages (May 2012) DOI: /bja/aes001 Copyright © 2012 The Author(s) Terms and Conditions

2 Fig 1 (a) Box plot showing pain intensity and unpleasantness produced by 43°C and 48°C heat stimuli, and CPT in 29 volunteers. The end of the boxes presents the 25th and 75th percentiles, with a line at the median and error bars define 10th and 90th percentiles. The pain intensity and unpleasantness for all three stimuli were significantly different from each other (P<0.001). For the CPT, the NRS value at the time of withdrawal of the hand from water is shown. (b) Pain intensity during CPT and the unpleasantness of the test in 29 volunteers. The subjects immersed their right hand and wrist into +3°C water for as long as they could tolerate it but no longer than 90 s. Dotted lines represent individual subjects and the continuous line indicates the mean value. British Journal of Anaesthesia  , DOI: ( /bja/aes001) Copyright © 2012 The Author(s) Terms and Conditions

3 Fig 2 Changes in the PPGA after 43°C and 48°C heat stimuli, and CPT in 29 volunteers. British Journal of Anaesthesia  , DOI: ( /bja/aes001) Copyright © 2012 The Author(s) Terms and Conditions

4 Fig 3 Changes in HR and ANSSi during three thermal stimuli (43°C and 48°C, CPT) in one subject. British Journal of Anaesthesia  , DOI: ( /bja/aes001) Copyright © 2012 The Author(s) Terms and Conditions

5 Fig 4 Changes in HR, PPGA, SPI, and ANSSi during CPT in 29 healthy volunteers. Dotted lines indicate the individual subjects and the continuous line shows the mean values. British Journal of Anaesthesia  , DOI: ( /bja/aes001) Copyright © 2012 The Author(s) Terms and Conditions

6 Fig 5 ANSSi and pain intensity (VAS/NRS) before and after thermal stimuli in 29 healthy volunteers. The difference between ANSSi at 43°C and 48°C was not statistically significant. ANSSi was significantly greater after CPT than after the 48°C heat stimulus (P<0.001). British Journal of Anaesthesia  , DOI: ( /bja/aes001) Copyright © 2012 The Author(s) Terms and Conditions

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