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Volume 64, Issue 1, Pages 263-271 (July 2003)
Coronary artery, aortic wall, and valvular calcification in nondialyzed individuals with type 2 diabetes and renal disease Raffi Merjanian, Matthew Budoff, Sharon Adler, Nancy Berman, Rajnish Mehrotra Kidney International Volume 64, Issue 1, Pages (July 2003) DOI: /j x Copyright © 2003 International Society of Nephrology Terms and Conditions
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Figure 1 The prevalence of coronary artery, aortic wall, aortic valve and mitral valve calcification in individuals with diabetic renal disease (N = 32), diabetic controls (N = 18) and in nondiabetic controls (N = 95). Compared to diabetic controls, individuals with diabetic renal disease had a significantly greater prevalence of aortic wall calcification (66% vs. 22%, P = 0.008). Compared to nondiabetic controls, individuals with diabetic renal disease had a significantly greater prevalence of coronary artery calcification (94% vs. 59%, P < 0.001), aortic wall calcification (66% vs. 35%, P = 0.004), aortic valve calcification (23% vs. 6%, P = 0.02), and mitral valve calcification (25% vs. 2%, P < 0.001). Kidney International , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions
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Figure 2 The range of coronary artery calcification scores in diabetic renal disease individuals, diabetic controls, and nondiabetic controls. There was a significant difference in the range of distribution of coronary artery calcification scores between individuals with diabetic renal disease and nondiabetic controls (P < 0.001). Severe calcification (score>400) was present in 41% of individuals with diabetic renal disease compared to 11% of diabetic controls (P = 0.06) and 9% of nondiabetic controls (P < 0.001). Kidney International , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions
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Figure 3 The median coronary artery and aortic wall calcification scores in diabetic renal disease individuals (DRD) (N = 32), diabetic controls (N = 18) and in nondiabetic controls (N = 95). The horizontal lines (from top to bottom) represent the 75th and 25th percentile for the scores in individuals with diabetic renal disease and among controls. The median coronary artery calcification scores were significantly greater in individuals with diabetic renal disease than among diabetic controls [238 (55 to 789) vs. 96 (12 to 202), P = ] or nondiabetic controls [238 (55 to 789) vs. 10 (0 to 90), P < 0.001]. Similarly, the aortic wall calcification scores were significantly greater in individuals with diabetic renal disease than among nondiabetic controls [127 (0 to 520) vs. 0 (0 to 42), P = 0.001]. The median aortic wall calcification score, as well as the interquartile range among diabetic controls was 0 and was significantly lower than among individuals with diabetic renal disease (P = 0.004). Thus, these data are not presented in the figure. Kidney International , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions
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Figure 4 Box and whisker plots for the coronary artery and aortic wall calcification scores in diabetic renal disease individuals with (N = 15) and without known coronary artery disease (CAD) (N = 17). The horizontal lines (from top to bottom) represent the maximum, 90th, 75th, 50th, 25th, and 10th percentiles. The median coronary artery calcification scores were significantly greater in individuals with known CAD compared to those without [543 (232 to 894) vs. 74 (14 to 257), P = 0.004]. The aortic wall calcification scores were significantly greater in individuals with known CAD compared to those without [427 (155 to 829) vs. 0 (0 to 88), P = 0.003]. Kidney International , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions
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