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Reinduction With Certolizumab Pegol in Patients With Relapsed Crohn's Disease: Results From the PRECiSE 4 Study  William J. Sandborn, Stefan Schreiber,

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Presentation on theme: "Reinduction With Certolizumab Pegol in Patients With Relapsed Crohn's Disease: Results From the PRECiSE 4 Study  William J. Sandborn, Stefan Schreiber,"— Presentation transcript:

1 Reinduction With Certolizumab Pegol in Patients With Relapsed Crohn's Disease: Results From the PRECiSE 4 Study  William J. Sandborn, Stefan Schreiber, Stephen B. Hanauer, Jean–Frédéric Colombel, Ralph Bloomfield, Gary R. Lichtenstein  Clinical Gastroenterology and Hepatology  Volume 8, Issue 8, Pages e1 (August 2010) DOI: /j.cgh Copyright © 2010 AGA Institute Terms and Conditions

2 Figure 1 Study design. czp, certolizumab pegol.
Clinical Gastroenterology and Hepatology 2010 8, e1DOI: ( /j.cgh ) Copyright © 2010 AGA Institute Terms and Conditions

3 Figure 2 (A) Response rates (reduction from week 0 in HBI score of ≥3) and (B) remission rates (HBI score of ≤4) in PRECiSE 4 (intention-to-treat population). Clinical Gastroenterology and Hepatology 2010 8, e1DOI: ( /j.cgh ) Copyright © 2010 AGA Institute Terms and Conditions

4 Figure 3 Geometric mean plasma concentration of certolizumab pegol (95% confidence interval) in patients with or without anti–certolizumab pegol antibodies. (A) Group A (drug interruption group), (B) group B (continuous maintenance group). czp, certolizumab pegol. Clinical Gastroenterology and Hepatology 2010 8, e1DOI: ( /j.cgh ) Copyright © 2010 AGA Institute Terms and Conditions


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