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Inflammatory cell and epithelial characteristics of perennial allergic and nonallergic rhinitis with a symptom history of 1 to 3 years’ duration  Kawa.

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Presentation on theme: "Inflammatory cell and epithelial characteristics of perennial allergic and nonallergic rhinitis with a symptom history of 1 to 3 years’ duration  Kawa."— Presentation transcript:

1 Inflammatory cell and epithelial characteristics of perennial allergic and nonallergic rhinitis with a symptom history of 1 to 3 years’ duration  Kawa Amin, PhDa,e, Juhani Rinne, MD, PhDb, Tari Haahtela, MD, PhDb, Markku Simola, MDb, Christer G.B. Peterson, PhDc, Godfried M. Roomans, PhDa, Henrik Malmberg, MD, PhDc, Per Venge, MD, PhDe, Lahja Sevéus, PhDe  Journal of Allergy and Clinical Immunology  Volume 107, Issue 2, Pages (February 2001) DOI: /mai Copyright © 2001 Mosby, Inc. Terms and Conditions

2 Fig. 1 Comparison of the number of inflammatory cells in nasal biopsy specimens as evaluated by immunohistochemical methods. The number of EPO+ cells (a) , EG2+ cells (b) , MPO+ cells (c) , HNL+ cells (d) , and AA1+ cells (e) per square millimeter of tissue in control subjects (C) , patients with PAR with biopsy specimen taken out of season, patients with PAR with biopsy specimen taken during the pollen season, and PNAR. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

3 Fig. 2 Immunocytochemical staining of nasal biopsy specimens for EPO in patients with PNAR (a) , EPO in patients in the PARoutside eseason group (b) , EPO in patients in the PARseason group (c) , and MPO in patients with PNAR (d) . This figure shows that many EPO+ cells are present in the submucosa and epithelium of patients with PNAR (a) and that a high number of eosinophils and high release activity can be found associated with areas of epithelial damage in patients in the PARoutside season group (b) . The eosinophils were weakly positive and often disintegrating in patients in the PARseason group (c) , and staining for MPO+ cells in patients with PNAR (d) was intensive, indicating a high number of neutrophils and high release activity in areas with epithelial damage. (Original magnification, 420×; Mayer’s hematoxylin.) Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

4 Fig. 3 a, Nasal mucous membrane of patients with PNAR stained for EPO. Degranulating (Deg) cells are indicated by arrows . b, Nasal mucous membrane of patients in the PARoutside season group stained for EPO. Degranulating eosinophils (Deg eos) are indicated by arrows . The figure also shows neutrophils (Neu) visualized with hematoxylin staining. c, Patients the in PARseason group with degranulated empty eosinophils (staining for EG2). d, The same patient group, showing staining of neutrophils with EG2. (Original magnification, 1050×; Mayer’s hematoxylin.) Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

5 Fig. 4 Staining of tissue mast cells with AA1 in patients with PNAR (a) , patients in the PARoutside season group (b) , patients in the PARseason group (c) , and control subjects (d) , respectively. (Original magnification, 420×; Mayer’s hematoxylin.) Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

6 Fig. 5 The epithelial integrity of the nasal mucous membrane in control subjects (C) , patients in the PARoutside season group, patients in the PARseason group, and patients with PNAR. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

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