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Chapter 6 A Tour of the Cell.

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1 Chapter 6 A Tour of the Cell

2 Overview: The Importance of Cells
All organisms are made of cells The cell is the simplest collection of matter that can live

3 Cell structure is correlated to cellular function
10 µm Figure 6.1

4 A smaller cell Has a higher surface to volume ratio, which facilitates the exchange of materials into and out of the cell Surface area increases while total volume remains constant 5 1 Total surface area (height  width  number of sides  number of boxes) Total volume (height  width  length  number of boxes) Surface-to-volume ratio (surface area  volume) 6 150 125 12 750 Figure 6.7

5 (b) Structure of the plasma membrane
Functions as a selective barrier Allows sufficient passage of nutrients and waste Outside of cell Inside of cell Hydrophilic region Hydrophobic (b) Structure of the plasma membrane Phospholipid Proteins TEM of a plasma membrane. The plasma membrane, here in a red blood cell, appears as a pair of dark bands separated by a light band. (a) 0.1 µm Carbohydrate side chain Figure 6.8 A, B

6 Intermediate filaments ENDOPLASMIC RETICULUM (ER)
A animal cell Rough ER Smooth ER Centrosome CYTOSKELETON Microfilaments Microtubules Microvilli Peroxisome Lysosome Golgi apparatus Ribosomes In animal cells but not plant cells: Lysosomes Centrioles Flagella (in some plant sperm) Nucleolus Chromatin NUCLEUS Flagelium Intermediate filaments ENDOPLASMIC RETICULUM (ER) Mitochondrion Nuclear envelope Plasma membrane Figure 6.9

7 Concept 6.3: The eukaryotic cell’s genetic instructions are housed in the nucleus and carried out by the ribosomes

8 The Nucleus: Genetic Library of the Cell
Contains most of the genes in the eukaryotic cell

9 The nuclear envelope Encloses the nucleus, separating its contents from the cytoplasm Nucleus Nucleolus Chromatin Nuclear envelope: Inner membrane Outer membrane Nuclear pore Rough ER Pore complex Surface of nuclear envelope. Pore complexes (TEM). Nuclear lamina (TEM). Close-up of nuclear envelope Ribosome 1 µm 0.25 µm Figure 6.10

10 Ribosomes: Protein Factories in the Cell
Are particles made of ribosomal RNA and protein

11 TEM showing ER and ribosomes
Carry out protein synthesis Ribosomes Cytosol Free ribosomes Bound ribosomes Large subunit Small TEM showing ER and ribosomes Diagram of a ribosome 0.5 µm ER Endoplasmic reticulum (ER) Figure 6.11

12 The endomembrane system
Concept 6.4: The endomembrane system regulates protein traffic and performs metabolic functions in the cell The endomembrane system Includes many different structures

13 The Endoplasmic Reticulum: Biosynthetic Factory
The endoplasmic reticulum (ER) Accounts for more than half the total membrane in many eukaryotic cells

14 The ER membrane Is continuous with the nuclear envelope Figure 6.12
Smooth ER Rough ER ER lumen Cisternae Ribosomes Transport vesicle Transitional ER 200 µm Nuclear envelope Figure 6.12

15 There are two distinct regions of ER
Smooth ER, which lacks ribosomes Rough ER, which contains ribosomes

16 Functions of Smooth ER The smooth ER Synthesizes lipids
Metabolizes carbohydrates Stores calcium Detoxifies poison

17 Functions of Rough ER The rough ER Has bound ribosomes
Produces proteins and membranes, which are distributed by transport vesicles

18 The Golgi Apparatus: Shipping and Receiving Center
Receives many of the transport vesicles produced in the rough ER Consists of flattened membranous sacs called cisternae

19 Functions of the Golgi apparatus include
Modification of the products of the rough ER Manufacture of certain macromolecules

20 Functions of the Golgi apparatus
cis face (“receiving” side of Golgi apparatus) Vesicles move from ER to Golgi Vesicles also transport certain proteins back to ER Vesicles coalesce to form new cis Golgi cisternae Cisternal maturation: Golgi cisternae move in a cis- to-trans direction Vesicles form and leave Golgi, carrying specific proteins to other locations or to the plasma mem- brane for secretion Vesicles transport specific proteins backward to newer Cisternae trans face (“shipping” side of 0.1 0 µm 1 6 5 2 3 4 Golgi apparatus Figure 6.13 TEM of Golgi apparatus

21 Lysosomes: Digestive Compartments
A lysosome Is a membranous sac of hydrolytic enzymes Can digest all kinds of macromolecules

22 (a) Phagocytosis: lysosome digesting food
Lysosomes carry out intracellular digestion by Phagocytosis (a) Phagocytosis: lysosome digesting food 1 µm Lysosome contains active hydrolytic enzymes Food vacuole fuses with lysosome Hydrolytic enzymes digest food particles Digestion Food vacuole Plasma membrane Lysosome Digestive Nucleus Figure 6.14 A

23 (b) Autophagy: lysosome breaking down damaged organelle
Lysosome containing two damaged organelles 1 µ m Mitochondrion fragment Peroxisome Lysosome fuses with vesicle containing damaged organelle Hydrolytic enzymes digest organelle components Vesicle containing damaged mitochondrion Digestion Lysosome Figure 6.14 B

24 Relationships among organelles of the endomembrane system
Plasma membrane expands by fusion of vesicles; proteins are secreted from cell Transport vesicle carries proteins to plasma membrane for secretion Lysosome available for fusion with another vesicle for digestion 4 5 6 Nuclear envelope is connected to rough ER, which is also continuous with smooth ER Nucleus Rough ER Smooth ER cis Golgi trans Golgi Membranes and proteins produced by the ER flow in the form of transport vesicles to the Golgi Nuclear envelop Golgi pinches off transport Vesicles and other vesicles that give rise to lysosomes and Vacuoles 1 3 2 Plasma membrane Figure 6.16

25 Mitochondria Are found in nearly all eukaryotic cells
Are the sites of cellular respiration

26 Mitochondria are enclosed by two membranes
A smooth outer membrane An inner membrane folded into cristae Mitochondrion Intermembrane space Outer membrane Free ribosomes in the mitochondrial matrix Mitochondrial DNA Inner Cristae Matrix 100 µm Figure 6.17

27 Peroxisomes: Oxidation
Produce hydrogen peroxide and convert it to water Chloroplast Peroxisome Mitochondrion 1 µm Figure 6.19

28 Concept 6.6: The cytoskeleton is a network of fibers that organizes structures and activities in the cell

29 The cytoskeleton Is a network of fibers extending throughout the cytoplasm Microtubule 0.25 µm Microfilaments Figure 6.20 Figure 6.20

30 Roles of the Cytoskeleton: Support, Motility, and Regulation
The cytoskeleton is a network of fibers that organizes structures and activities in the cell Gives mechanical support to the cell

31 Is involved in cell motility, which utilizes motor proteins
Vesicle ATP Receptor for motor protein Motor protein (ATP powered) Microtubule of cytoskeleton (a) Motor proteins that attach to receptors on organelles can “walk” the organelles along microtubules or, in some cases, microfilaments. Vesicles 0.25 µm (b) Vesicles containing neurotransmitters migrate to the tips of nerve cell axons via the mechanism in (a). In this SEM of a squid giant axon, two  vesicles can be seen moving along a microtubule. (A separate part of the experiment provided the evidence that they were in fact moving.) Figure 6.21 A, B

32 There are three main types of fibers that make up the cytoskeleton
Table 6.1

33 Microtubules Microtubules Shape the cell Guide movement of organelles
Help separate the chromosome copies in dividing cells

34 Is considered to be a “microtubule-organizing center”
Contains a pair of centrioles Centrosome Microtubule Centrioles 0.25 µm Longitudinal section of one centriole Microtubules Cross section of the other centriole Figure 6.22

35 Cilia and Flagella Cilia and flagella
Contain specialized arrangements of microtubules Are locomotor appendages of some cells

36 Flagella beating pattern
(a) Motion of flagella. A flagellum usually undulates, its snakelike motion driving a cell in the same direction as the axis of the flagellum. Propulsion of a human sperm cell is an example of flagellatelocomotion (LM). 1 µm Direction of swimming Figure 6.23 A

37 Ciliary motion Figure 6.23 B (b) Motion of cilia. Cilia have a back-
and-forth motion that moves the cell in a direction perpendicular to the axis of the cilium. A dense nap of cilia, beating at a rate of about 40 to 60 strokes a second, covers this Colpidium, a freshwater protozoan (SEM). Figure 6.23 B 15 µm

38 Cross section of basal body
Cilia and flagella share a common ultrastructure (a) (c) (b) Outer microtubule doublet Dynein arms Central microtubule Outer doublets cross-linking proteins inside Radial spoke Plasma membrane Microtubules Basal body 0.5 µm 0.1 µm Cross section of basal body Triplet Figure 6.24 A-C

39 The protein dynein Is responsible for the bending movement of cilia and flagella Microtubule doublets ATP Dynein arm Powered by ATP, the dynein arms of one microtubule doublet grip the adjacent doublet, push it up, release, and then grip again. If the two microtubule doublets were not attached, they would slide relative to each other. (a) Figure 6.25 A

40 they are physically restrained by proteins, so they bend. (Only two of
Outer doublets cross-linking proteins Anchorage in cell ATP In a cilium or flagellum, two adjacent doublets cannot slide far because they are physically restrained by proteins, so they bend. (Only two of the nine outer doublets in Figure 6.24b are shown here.) (b) Figure 6.25 B

41 Microfilaments (Actin Filaments)
Are built from molecules of the protein actin

42 Intermediate filaments
Are found in microvilli 0.25 µm Microvillus Plasma membrane Microfilaments (actin filaments) Intermediate filaments Figure 6.26

43 Microfilaments that function in cellular motility
Contain the protein myosin in addition to actin Actin filament Myosin filament Myosin motors in muscle cell contraction. (a) Muscle cell Myosin arm Figure 6.27 A

44 Amoeboid movement Involves the contraction of actin and myosin filaments Cortex (outer cytoplasm): gel with actin network Inner cytoplasm: sol with actin subunits Extending pseudopodium (b) Amoeboid movement Figure 6.27 B

45 Intermediate Filaments
Support cell shape Fix organelles in place

46 Concept 6.7: Extracellular components and connections between cells help coordinate cellular activities

47 The ECM = Cell Membrane Is made up of glycoproteins and other macromolecules Collagen Fibronectin Plasma membrane EXTRACELLULAR FLUID Micro- filaments CYTOPLASM Integrins Polysaccharide molecule Carbo- hydrates Proteoglycan Core protein Integrin Figure 6.29 A proteoglycan complex

48 Functions of the ECM include
Support Adhesion Movement Regulation

49 Animals: Tight Junctions, Desmosomes, and Gap Junctions
There are three types of intercellular junctions; Tight junctions Desmosomes Gap junctions

50 Types of intercellular junctions in animals
Tight junctions prevent fluid from moving across a layer of cells Tight junction 0.5 µm 1 µm Space between cells Plasma membranes of adjacent cells Extracellular matrix Gap junction Tight junctions 0.1 µm Intermediate filaments Desmosome Gap junctions At tight junctions, the membranes of neighboring cells are very tightly pressed against each other, bound together by specific proteins (purple). Forming continu- ous seals around the cells, tight junctions prevent leakage of extracellular fluid across A layer of epithelial cells. Desmosomes (also called anchoring junctions) function like rivets, fastening cells Together into strong sheets. Intermediate Filaments made of sturdy keratin proteins Anchor desmosomes in the cytoplasm. Gap junctions (also called communicating junctions) provide cytoplasmic channels from one cell to an adjacent cell. Gap junctions consist of special membrane proteins that surround a pore through which ions, sugars, amino acids, and other small molecules may pass. Gap junctions are necessary for commu- nication between cells in many types of tissues, including heart muscle and animal embryos. TIGHT JUNCTIONS DESMOSOMES GAP JUNCTIONS Figure 6.31

51 The Cell: A Living Unit Greater Than the Sum of Its Parts
Cells rely on the integration of structures and organelles in order to function 5 µm Figure 6.32

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