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The Hormonal Control of Food Intake

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1 The Hormonal Control of Food Intake
Anthony P. Coll, I. Sadaf Farooqi, Stephen O'Rahilly  Cell  Volume 129, Issue 2, Pages (April 2007) DOI: /j.cell Copyright © 2007 Elsevier Inc. Terms and Conditions

2 Figure 1 Control of Food Intake by the Hypothalamic Leptin-Melanocortin Pathway The hypothalamus receives and integrates neural, metabolic, and hormonal signals to regulate energy homeostasis. In particular, the adipocyte-derived hormone leptin and the melanocortin pathway have a critical role in the control of food intake. AgRP, Agouti-related protein; Arc, arcuate nucleus; MC4R, melanocortin 4 receptor; POMC, pro-opiomelanocortin; PVN, paraventricular nucleus. Cell  , DOI: ( /j.cell ) Copyright © 2007 Elsevier Inc. Terms and Conditions

3 Figure 2 Hormones from the Gut and Endocrine Organs Affect Food Intake
Hormonal signals derived from the gut and classical endocrine organs, such as the pancreas, thyroid, and adrenal glands act in synergy to effect changes in feeding behavior. CCK, cholecystokinin; OXM, oxyntomodulin; GLP-1, glucagon-like peptide 1; PYY3–36, peptide YY3–36. Cell  , DOI: ( /j.cell ) Copyright © 2007 Elsevier Inc. Terms and Conditions

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