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The effect of ischemia/reperfusion on adenine nucleotide metabolism and xanthine oxidase production in skeletal muscle  Thomas F. Lindsay, MD, Shinta.

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Presentation on theme: "The effect of ischemia/reperfusion on adenine nucleotide metabolism and xanthine oxidase production in skeletal muscle  Thomas F. Lindsay, MD, Shinta."— Presentation transcript:

1 The effect of ischemia/reperfusion on adenine nucleotide metabolism and xanthine oxidase production in skeletal muscle  Thomas F. Lindsay, MD, Shinta Liauw, MSc, Alex D. Romaschin, PhD, Paul M. Walker, MD, PhD, FRCS(C)  Journal of Vascular Surgery  Volume 12, Issue 1, Pages 8-15 (July 1990) DOI: / (90)90360-M Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

2 Fig. 1 Creatine phosphate (CP) levels in μmol/gm/dry weight, at preischemia (PI), end ischemia (EI), and at 5 to 45 minutes of reperfusion. Solid dots = 4 hours and open dots = 5 hours of ischemic stress (mean ± SEM, n = 8). Journal of Vascular Surgery  , 8-15DOI: ( / (90)90360-M) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

3 Fig. 2 Energy charge potential (ECP) at preischemia (PI), end ischemia (EI), and at 5 to 45 minutes of reperfusion. Solid dots = 4 hours and open dots = 5 hours of ischemic stress (mean ± SEM, n = 8). Journal of Vascular Surgery  , 8-15DOI: ( / (90)90360-M) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

4 Fig. 3 The relationship between ATP/ADP ratio and intracellular stores of CP is demonstrated at end ischemia and at 5, 15, 30, 45 minutes of reperfusion (n = 8, r = 0.72, p < 0.05). Journal of Vascular Surgery  , 8-15DOI: ( / (90)90360-M) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions


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