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Maternal asthma and microRNA regulation of soluble HLA-G in the airway

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Presentation on theme: "Maternal asthma and microRNA regulation of soluble HLA-G in the airway"— Presentation transcript:

1 Maternal asthma and microRNA regulation of soluble HLA-G in the airway
Jessie Nicodemus-Johnson, PhD, Bharathi Laxman, PhD, Randi K. Stern, BS, Jyotsna Sudi, MS, Courtney N. Tierney, MPH, Lourdes Norwick, RN, Douglas K. Hogarth, MD, John F. McConville, MD, Edward T. Naureckas, MD, Anne I. Sperling, PhD, Julian Solway, MD, Jerry A. Krishnan, MD, PhD, Dan L. Nicolae, PhD, Steven R. White, MD, Carole Ober, PhD  Journal of Allergy and Clinical Immunology  Volume 131, Issue 6, Pages e4 (June 2013) DOI: /j.jaci Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 sHLA-G concentrations stratified by genotype in BAL fluid and plasma. A and B, HLA-G +3142 (left panels, x-axis) and +36 (right panels) genotypes and normalized sHLA-G concentrations in BAL fluid (Fig 1, A) and plasma (Fig 1, B). C, +3142 and +36 HLA-G genotypes and transcript levels in airway epithelial cells. Gray boxes represent the interquartile range, encompassing the first through third quartiles; the horizontal bar shows the median value. Values greater than 1.5 times the interquartile range are plotted outside of the whiskers. P values are from linear regression assuming an additive model. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 sHLA-G concentrations in BAL fluid and plasma stratified by maternal asthma status. Normalized sHLA-G concentrations in BAL fluid (A) and plasma (B) are shown. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 sHLA-G concentrations stratified by genotype in subjects with and without a history of maternal asthma. HLA-G genotypes at +3142 (A) and +36 (B) are associated with sHLA-G concentrations in BAL fluid from subjects with an asthmatic mother but not in subjects with a nonasthmatic mother. The P values for an interaction effect between maternal asthma and HLA-G genotype in the child on sHLA-G concentrations in BAL fluid is for HLA-G +3142 and 0.12 for HLA-G +36. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 miR-152 family levels stratified by maternal asthma status. Levels of the miR-152 family in the airways of adult children with an asthmatic mother (A-C) and in circulating white blood cells (D-F) are shown. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig E1 Plasma sHLA-G concentrations vary by ethnicity. A, Plasma sHLA-G concentrations stratified by ethnicity. B, BAL fluid sHLA-G concentrations stratified by ethnicity. AFA, African American ancestry; EA, European ancestry. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig E2 A-C, Airway epithelial cell miR-152 family levels in BAL fluid from the African American–only sample stratified by maternal asthma status. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

8 Fig E3 HLA-G protein and transcript abundance in the African American–only subgroup. A, Normalized BAL fluid sHLA-G concentrations in the African American–only sample stratified by genotype at +3142 and +36. B and C, Normalized Plasma sHLA-G concentrations (Fig E3, B) and normalized airway epithelial cell sHLA-G abundance (Fig E3, C) stratified by +3142 and +36 genotype from the African American subgroup. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

9 Fig E4 HLA-G genotype and sHLA-G concentrations in BAL fluid stratified by maternal asthma status and the +3142 (A) and +36 (B) genotypes. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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