1. Long-Lived Plasma Cells Have a Sweet Tooth
Lynn M. Corcoran, Stephen L. Nutt 
Immunity 
Volume 45, Issue 1, Pages 3-5 (July 2016)
DOI: /j.immuni
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1
The Molecular and Cellular Components of the Long-Lived Plasma Cell Survival Niche
Plasma cells are recruited to the bone marrow through their responsiveness to the chemokine CXCL12 and cellular adhesion molecules on bone marrow stromal cells. A variety of hematopoietic cell types, including eosinophils (shown), secrete the survival factors APRIL and IL-6. The transcription factors IRF4 and ZBTB20 are known to also control plasma cell survival. LLPC take up large amounts of glucose through their high expression of cell surface Glut1. Glucose is processed to fructose-6-phosphate, the majority of which is consumed by the hexosamine biosynthesis pathway during the glycosylation of antibody molecules, while a minority is converted to pyruvate, taken up into mitochondria by the transporter Mpc2, and used in respiration. Collectively, the high glucose uptake promotes LLPC survival and antibody secretion.
Immunity  , 3-5DOI: ( /j.immuni )
Copyright © 2016 Elsevier Inc. Terms and Conditions