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Remodeling KRAS Structure
Daniel J. Deredge, Patrick L. Wintrode Structure Volume 25, Issue 9, Pages (September 2017) DOI: /j.str Copyright © 2017 Elsevier Ltd Terms and Conditions
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Figure 1 Structure of KRAS with Switch II Pocket Inhibitors and GDP
A GDP bound KRAS structure (4OBE) in gray was superimposed with KRAS G12C structures bound to covalent inhibitors (5F2E in magenta, 4MLO in blue) binding in the switch II pocket. The switch II pocket conformation is color coded to the ligand (ARS853, magenta; vinylsulfonamide 7, blue). The G12C residue was rendered in yellow spherical representation. GDP is rendered in orange stick representation. Structure , DOI: ( /j.str ) Copyright © 2017 Elsevier Ltd Terms and Conditions
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