1. Hippo Signaling Maintains the Phenotype of Pancreatic Acinar Cells
Beatriz Sosa–Pineda 
Gastroenterology 
Volume 144, Issue 7, Pages (June 2013)
DOI: /j.gastro
Copyright © 2013 AGA Institute Terms and Conditions

2. Figure 1
(A) Schematics of core components and downstream effectors of the Hippo pathway in vertebrates (additional pathway regulators are not included in this diagram). (B) YAP proteins localize to the nucleus (green) of cells located in the “trunk” region (CK19+, pink) in E15.5 pancreata. This region harbors the precursors of ductal and islet cells.15 Low YAP expression has been reported17 in the cytoplasm (green) of tip/acinar cells at E15.5. Pancreatic deletion of Mst1/2 does not have any major consequences at this stage. (C) Mst1, Mst2 and Yap are not expressed in acinar (yellow) or ductal (pink) cells in the pancreas of newborn mice. Acinar cells lacking Mst1/2 are indistinguishable from those of wild-type pancreata at this stage. (D) Yap proteins localize to the nucleus (green) of ductal cells (CK19+), but are absent in acinar cells, in adult pancreata. (E) Progressive formation of “hybrid” structures expressing acinar (yellow) and ductal (pink) markers occurs throughout the Mst1/2 DKO pancreas after P14. YAP proteins localize to the nucleus in both “acinar” and “ductal” cells in these hybrid structures. (F) Tubular structures expressing ductal markers are abundant in the Mst1/2 DKO pancreas at 1 month. (G) “Hybrid” structures displaying colocalization of acinar and ductal markers are also observed in the pancreas of mice upon induction of acute pancreatitis (AP) with cerulein.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2013 AGA Institute Terms and Conditions