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Shining a LAMP on pauci-immune focal segmental glomerulonephritis

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Presentation on theme: "Shining a LAMP on pauci-immune focal segmental glomerulonephritis"— Presentation transcript:

1 Shining a LAMP on pauci-immune focal segmental glomerulonephritis
Alan D. Salama, Charles D. Pusey  Kidney International  Volume 76, Issue 1, Pages (July 2009) DOI: /ki Copyright © 2009 International Society of Nephrology Terms and Conditions

2 Figure 1 Photomicrograph of a renal biopsy from a patient with active ANCA-associated vasculitis (AAV), demonstrating crescentic glomerulonephritis and fibrinoid necrosis in the glomerular tuft. Silver stain. Magnification × 400. Courtesy of Dr Candice Roufosse, Department of Histopathology, Hammersmith Hospital. Kidney International  , 15-17DOI: ( /ki ) Copyright © 2009 International Society of Nephrology Terms and Conditions

3 Figure 2 Sketch demonstrating the proposed mechanism of molecular mimicry inducing immune responsiveness to bacterial fimbrial protein and in turn lysosomal-associated membrane protein (LAMP-2), resulting in activation of circulating neutrophils and damage to glomerular endothelial cells. Kidney International  , 15-17DOI: ( /ki ) Copyright © 2009 International Society of Nephrology Terms and Conditions


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