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Comparison of the observed and calculated CLR values of taurine and GCDCA-S. Comparison of the observed and calculated CLR values of taurine and GCDCA-S.

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Presentation on theme: "Comparison of the observed and calculated CLR values of taurine and GCDCA-S. Comparison of the observed and calculated CLR values of taurine and GCDCA-S."— Presentation transcript:

1 Comparison of the observed and calculated CLR values of taurine and GCDCA-S.
Comparison of the observed and calculated CLR values of taurine and GCDCA-S. The CLR of taurine and GCDCA-S values were calculated using control values, Ki for OAT1 or OAT3, and the geometric mean of the unbound probenecid concentrations from time zero to 8 hours. Three Ki values were used for calculation: in vitro Ki, 2 × Ki, and 0.5 × Ki. Yuri Tsuruya et al. Drug Metab Dispos 2016;44: Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

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