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Volume 136, Issue 5, Pages 1618-1628.e2 (May 2009)
Peginterferon alfa-2b and Ribavirin: Effective in Patients With Hepatitis C Who Failed Interferon alfa/Ribavirin Therapy Thierry Poynard, Massimo Colombo, Jordi Bruix, Eugene Schiff, Ruben Terg, Steven Flamm, Ricardo Moreno-Otero, Flair Carrilho, Warren Schmidt, Thomas Berg, Thomas McGarrity, E. Jenny Heathcote, Fernando Gonçales, Moises Diago, Antonio Craxi, Marcelo Silva, Pierre Bedossa, Pabak Mukhopadhyay, Louis Griffel, Margaret Burroughs, Clifford Brass, Janice Albrecht Gastroenterology Volume 136, Issue 5, Pages e2 (May 2009) DOI: /j.gastro Copyright © 2009 AGA Institute Terms and Conditions
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Figure 1 Patient flow and EPIC3 study design. HCV, hepatitis C virus; GCP, good clinical practice. *Data needed to calculate a log change at week 12 were missing for 184 patients. Of these patients, 175 continued participation in the retreatment study, and 9 either entered one of the maintenance protocols or discontinued. †Continued in the protocol at the discretion of the investigator. ‡All considered treatment failures. Gastroenterology , e2DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions
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Figure 2 Sustained virologic response rates by METAVIR score overall and among patients with undetectable HCV-RNA at treatment week 12. SVR, sustained virologic response. aData missing for 2 patients; P < to each other based on Mantel–Haenszel χ2 test. bData missing for 1 patient; P = to each other based on Mantel–Haenszel χ2 test conducted on the group that was negative at treatment week 12. Gastroenterology , e2DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions
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