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Angiotensin converting enzyme inhibitor captopril modifies conditioned place preference induced by morphine and morphine withdrawal signs in rats  Hojjatallah.

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Presentation on theme: "Angiotensin converting enzyme inhibitor captopril modifies conditioned place preference induced by morphine and morphine withdrawal signs in rats  Hojjatallah."— Presentation transcript:

1 Angiotensin converting enzyme inhibitor captopril modifies conditioned place preference induced by morphine and morphine withdrawal signs in rats  Hojjatallah Alaei, Mahmood Hosseini  Pathophysiology  Volume 14, Issue 1, Pages (May 2007) DOI: /j.pathophys Copyright © 2007 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 Comparison of the time spent in Morphine Compartment among saline, morphine, Ang II and captopril treated rats conditioned place preference induced by morphine. Data presented as mean±S.E.M. the time spent in the morphine compartment. (n=8 in each group) ***P<0.001 compared to saline group; (++)<0.01 compared to morphine group. Pathophysiology  , 55-60DOI: ( /j.pathophys ) Copyright © 2007 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 2 Comparison of morphine withdrawal signs precipitated by naloxone in morphine dependent rats receiving Ang II and captopril. Data presented as mean±S.E.M. of number of signs in 30min. Only about weight loss data presented as mean±S.E.M. of percent (n=8 in each group). *P<0.05,**P<0.01,***P<0.001 compared to morphine only group. There were no significant differences in weight losses (percent) in these three groups. Pathophysiology  , 55-60DOI: ( /j.pathophys ) Copyright © 2007 Elsevier Ireland Ltd Terms and Conditions


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