1. A Double-Blind, Randomized, Crossover Comparison Between Single-Dose and Double-Dose Immediate-Release Oral Morphine at Bedtime in Cancer Patients 
Ola Dale, MD, PhD, Maria Piribauer, MD, Stein Kaasa, MD, PhD, Kristin Moksnes, MD, Heidi Knobel, MD, PhD, Pål Klepstad, MD, PhD 
Journal of Pain and Symptom Management 
Volume 37, Issue 1, Pages (January 2009)
DOI: /j.jpainsymman
Copyright © 2009 U.S. Cancer Pain Relief Committee Terms and Conditions

2. Fig. 1
CONSORT flow sheet.
Journal of Pain and Symptom Management  , 68-76DOI: ( /j.jpainsymman )
Copyright © 2009 U.S. Cancer Pain Relief Committee Terms and Conditions

3. Fig. 2
Time course of serum concentrations (nmol/L) of morphine (upper panel) and M6G (lower panel) after SD and DD morphine. The individual variation is indicated by the median (minimum–maximum) morphine concentrations (nmol/L) at time 0: SD 25 (6–96); DD 21 (8–80), and similarly for M6G: SD 175 (28–455); DD: 139 (28–646).
Journal of Pain and Symptom Management  , 68-76DOI: ( /j.jpainsymman )
Copyright © 2009 U.S. Cancer Pain Relief Committee Terms and Conditions