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Redesigning the Architecture of the Base Pair: Toward Biochemical and Biological Function of New Genetic Sets  Andrew T. Krueger, Eric T. Kool  Chemistry.

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Presentation on theme: "Redesigning the Architecture of the Base Pair: Toward Biochemical and Biological Function of New Genetic Sets  Andrew T. Krueger, Eric T. Kool  Chemistry."— Presentation transcript:

1 Redesigning the Architecture of the Base Pair: Toward Biochemical and Biological Function of New Genetic Sets  Andrew T. Krueger, Eric T. Kool  Chemistry & Biology  Volume 16, Issue 3, Pages (March 2009) DOI: /j.chembiol Copyright © 2009 Elsevier Ltd Terms and Conditions

2 Figure 1 Examples of Base Pairs Designed to Augment the Natural Genetic Set Their dimensions are close to those of natural Watson-Crick pairs. R represents deoxyribose. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2009 Elsevier Ltd Terms and Conditions

3 Figure 2 Examples of DNA Base Replacements that Have Been Used for Probing Nucleobase Recognition Mechanisms Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2009 Elsevier Ltd Terms and Conditions

4 Figure 3 Novel Base-Pairing Systems Designed to Form New, Non-Purine-Pyrimidine Genetic Sets All have sizes larger than Watson-Crick pairs. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2009 Elsevier Ltd Terms and Conditions

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