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Role of endothelin and nitric oxide imbalance in the pathogenesis of hypoxia-induced arterial hypertension  Zhenmin Ni, Shahrooz Bemanian, Salah D. Kivlighn,

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Presentation on theme: "Role of endothelin and nitric oxide imbalance in the pathogenesis of hypoxia-induced arterial hypertension  Zhenmin Ni, Shahrooz Bemanian, Salah D. Kivlighn,"— Presentation transcript:

1 Role of endothelin and nitric oxide imbalance in the pathogenesis of hypoxia-induced arterial hypertension  Zhenmin Ni, Shahrooz Bemanian, Salah D. Kivlighn, Nosratola D. Vaziri  Kidney International  Volume 54, Issue 1, Pages (July 1998) DOI: /j x Copyright © 1998 International Society of Nephrology Terms and Conditions

2 Figure 1 Tail systolic blood pressure in placebo-treated rats exposed to hypobaric hypoxia (▪) and the control animals (★) kept at normal atmospheric pressure for 24days. N = 6 in each group; Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

3 Figure 2 Plasma concentration of endothelin (A) and urinary excretion of total nitrates and nitrites (NOx, B) in rats exposed to hypobaric hypoxia (•) and normoxia (♦) for 24days.N = 6 in each group. Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

4 Figure 3 Systolic arterial blood pressure in placebo-treated (▪), ET-A/B receptor blocker-treated (♦) and L-arginine-treated (★) rats exposed to hypobaric hypoxia for a 24-day period. A minimum of six animals were included in each group. Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

5 Figure 4 Urinary excretion of total nitrates and nitrites (NOx) in placebo-treated (•), L-arginine-treated (★) and ET-A/B receptor blocker-treated (♦) hypoxic groups. A minimum of six animals were included in each group. Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

6 Kidney International 1998 54, 188-192DOI: (10. 1046/j. 1523-1755. 1998
Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions


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