Download presentation
Presentation is loading. Please wait.
1
Microbial Molecules from the Multitudes within Us
Matthew R. Redinbo Cell Metabolism Volume 25, Issue 2, Pages (February 2017) DOI: /j.cmet Copyright © 2017 Elsevier Inc. Terms and Conditions
2
Figure 1 GI Microbiota Encode Biosynthetic Pathways Capable of Creating Molecules that Act on Human Targets The human gastrointestinal (GI) microbiota (left) encode nonribosomal peptide synthetase (NRPS) biosynthetic clusters that, when expressed in vitro in common laboratory bacteria (Escherichia coli, Bacillus subtilis), create novel metabolites. The compounds synthesized are structurally akin to human drugs and can inhibit human proteins, like the cathepsin proteases. Future questions include what other chemicals are manufactured by our microbiota (red), what signals the microbiota to create these compounds (blue), and what other human and bacterial targets do the compounds hit (green)? Cell Metabolism , DOI: ( /j.cmet ) Copyright © 2017 Elsevier Inc. Terms and Conditions
Similar presentations
© 2025 SlidePlayer.com. Inc.
All rights reserved.