1. Protein Chemical Modification on Endogenous Amino Acids
Emmanuel Baslé, Nicolas Joubert, Mathieu Pucheault 
Chemistry & Biology 
Volume 17, Issue 3, Pages (March 2010)
DOI: /j.chembiol
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2. Figure 1
Reactivity of Lysine, Arginine, Histidine, Aspartic Acid, Glutamic Acid, and C Termini
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3. Figure 2 Reactivity of Cysteine and Tyrosine
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4. Figure 3 Transition Metal-Catalyzed Bioconjugation
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5. Figure 4 Protein Photolabeling
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6. Figure 5 Oxidative Coupling and N Terminus Modification
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7. Figure 6 Main Applications of Protein Covalent Modification
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8. Figure 7 Examples of Trifunctional Probes
(A) Binding: arbutin; reaction: benzophenone biradical insertion; detection: purification with biotin (Qvit et al., 2008).
(B) Binding: brassinosteroid/BRII; reaction: carbene insertion with diazirine; detection: purification with biotin.
(C) Binding: benzensulfonamide/CAII; reaction: histidine epoxide opening; secondary detection by hydrazine-derived ligand/oxime-derived fluorescein exchange (Takaoka et al., 2006).
(D) Binding: benzensulfonamide/CAII; reaction: SN2 on tosylate; detection: fluorescence with 7-diethylaminocoumarin (Tsukiji et al., 2009b).
Chemistry & Biology  , DOI: ( /j.chembiol )
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