1. Lipoyl-E2-PDH Gets a Second Job
Seth W. Dickey, Michael Otto 
Cell Host & Microbe 
Volume 22, Issue 5, Pages (November 2017)
DOI: /j.chom
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2. Figure 1 Dual Roles of S. aureus Lipoyl-E2-PDH
Left: in the bacterial cytoplasm, lipoyl-E2-PDH (red) works with the E1 and E3 subunits to form the pyruvate dehydrogenase (PDH) multi-enzyme complex, which links glycolysis to the citric acid cycle by catalyzing the conversion of pyruvate to acetyl-CoA. Right: Grayczyk et al. (2017) discovered that S. aureus secretes lipoyl-E2-PDH where it moonlights outside to block activation of TLR1/2 on macrophages, suppressing the innate immune response to S. aureus infections.
Cell Host & Microbe  , DOI: ( /j.chom )
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