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Volume 102, Issue 10, Pages (May 2012)

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1 Volume 102, Issue 10, Pages 2372-2380 (May 2012)
Structure of Immune Stimulating Complex Matrices and Immune Stimulating Complexes in Suspension Determined by Small-Angle X-Ray Scattering  Jan Skov Pedersen, Cristiano L.P. Oliveira, Henriette Baun Hübschmann, Lise Arleth, Søren Manniche, Nicolai Kirkby, Hanne Mørck Nielsen  Biophysical Journal  Volume 102, Issue 10, Pages (May 2012) DOI: /j.bpj Copyright © 2012 Biophysical Society Terms and Conditions

2 Figure 1 Experimental SAXS data for the ISCOM matrices. The broken curve is the nonsmeared fit for the model described in the text, which consists of icosahedral, tennis ball, and football ball structures. The full curve is the actual fit to the data including the instrumental smearing. Biophysical Journal  , DOI: ( /j.bpj ) Copyright © 2012 Biophysical Society Terms and Conditions

3 Figure 2 Cryo-TEM image of ISCOMs in suspension visualized by cryo-TEM. Scale bar is 50 nm. For comparison, the ISCOM matrix structures derived from the SAXS data are also shown (nonscaled). Biophysical Journal  , DOI: ( /j.bpj ) Copyright © 2012 Biophysical Society Terms and Conditions

4 Figure 3 Size distribution weighted by the intensity of the ISCOM matrices measured with DLS. Biophysical Journal  , DOI: ( /j.bpj ) Copyright © 2012 Biophysical Society Terms and Conditions

5 Figure 4 ISCOM matrix structure from analysis of SAXS data. (A) Icosahedral structure. (B) Tennis ball structure. (C) Football structure. The tennis ball structure model has 12 pentagons and eight hexagons arranged as sketched in panel D. Biophysical Journal  , DOI: ( /j.bpj ) Copyright © 2012 Biophysical Society Terms and Conditions

6 Figure 5 Experimental SAXS data for ISCOM particles loaded with TT. The broken curve is the nonsmeared fit for the model described in the text. The full curve is the actual fit to the data including the instrumental smearing. Biophysical Journal  , DOI: ( /j.bpj ) Copyright © 2012 Biophysical Society Terms and Conditions

7 Figure 6 Suggested location of TT in the icosahedral, tennis ball, and football ISCOM structures. Biophysical Journal  , DOI: ( /j.bpj ) Copyright © 2012 Biophysical Society Terms and Conditions

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