1. Of Cilia and Cysts: Modeling Pancreatic Polycystic Disease
Klaus H. Kaestner 
Gastroenterology 
Volume 130, Issue 3, Pages (March 2006)
DOI: /j.gastro
Copyright © 2006 American Gastroenterological Association Terms and Conditions

2. Figure 1
Phenotype of the HNF-6 deficient pancreas. Schematic representation of acinar-ductal units normal (left) and HNF-6 null (right) pancreas. In wild-type pancreatic ducts, epithelial polarity is indicated by the presence of Mucin 1 (red) on the apical, and β-catenin (green) on the lateral surface of the cell. Each epithelial cell also contains a primary cilium. In the HNF-6 deficient pancreas, the intra-and interlobular ducts are abnormal, with the occurrence of multilayered epithelia with abnormal cellular polarity, the absence of primary cilia, and the formation of cysts. Illustration by Jerry Schoendorf, MAMS.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2006 American Gastroenterological Association Terms and Conditions

3. Figure 2
Proposed transcription factor network controlling differentiation of intra- and interlobular ducts. HNF-6 is required for the activation of genes that establish normal epithelial polarity. In addition, HNF-6 also regulates components of the primary cilium like Cystin and Polyductin. While Cystin is likely controlled by HNF-6 directly, the activation of Polyductin involves a transcription factor cascade with HNF-1β. Illustration by Jerry Schoendorf, MAMS.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2006 American Gastroenterological Association Terms and Conditions