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Zeng, Xin; Yin, Biaolin; Hu, Zheng; Liao, Chengzhong; Liu, Jinglei; Li, Shang; Li, Zheng; Nicklaus, Marc C.; Zhou, Guangbiao; Jiang, Sheng. Total synthesis.

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Presentation on theme: "Zeng, Xin; Yin, Biaolin; Hu, Zheng; Liao, Chengzhong; Liu, Jinglei; Li, Shang; Li, Zheng; Nicklaus, Marc C.; Zhou, Guangbiao; Jiang, Sheng. Total synthesis."— Presentation transcript:

1 Zeng, Xin; Yin, Biaolin; Hu, Zheng; Liao, Chengzhong; Liu, Jinglei; Li, Shang; Li, Zheng; Nicklaus, Marc C.; Zhou, Guangbiao; Jiang, Sheng. Total synthesis and biological evaluation of Largazole and derivatives with promising selectivity for cancers cells. Organic Letters (2010), 12(6),

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10 DIPEA = diisopropylethylamine
pKa of conjugate acid = 11

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13 Piperidine = pKa of conjugate acid = 11.24

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15 HOBt = 1-hydroxybenzotriazole
HOAt = 1-hydroxy-7-azabenzotriazole

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25 CSA = camphorsulfonic acid

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38 EDC = Ethyl dimethylaminopropyl carbodiimide

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