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Role of Cytotoxic T Cells in Chronic Alopecia Areata

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Presentation on theme: "Role of Cytotoxic T Cells in Chronic Alopecia Areata"— Presentation transcript:

1 Role of Cytotoxic T Cells in Chronic Alopecia Areata
Christine Bodemer, Yves de Prost  Journal of Investigative Dermatology  Volume 114, Issue 1, Pages (January 2000) DOI: /j x Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

2 Figure 1 Immunohistochemical study, with anti-IL1-β monoclonal antibody (α-IL-1), on chronic AA scalp biopsy specimen. A few intracytoplasmic labeled cells are observed in the mononuclear perifollicular infiltrate (arrow). Scale bars: 25 μm. Journal of Investigative Dermatology  , DOI: ( /j x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

3 Figure 2 Immunohistochemical study, with anti-Fas monoclonal antibody (anti-CD95). (A) On a chronic AA scalp biopsy specimen: Fas positivity was demonstrated at the cytoplasmic membrane of the hair follicle keratinocyte. Scale bars: 25 μm. (B) On a healthy human control follicle with absent anti-Fas staining. Scale bars: 25 μm. Journal of Investigative Dermatology  , DOI: ( /j x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

4 Figure 3 In situ hybridization study. In situ hybridization was performed on frozen sections of chronic AA scalp biopsy specimens, using 35S radiolabeled riboprobes. IL1β mRNA expression (A), INF-γ mRNA expression (B), and granzymeB mRNA expression (C) were detected in a few mononuclear cells located around the hair follicle (arrow). Scale bars: 25 μm. Journal of Investigative Dermatology  , DOI: ( /j x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions


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