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Primary Cutaneous Follicle Center Cell Lymphomas and Large B Cell Lymphomas of the Leg Descend from Germinal Center Cells. A Single Cell Polymerase Chain.

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Presentation on theme: "Primary Cutaneous Follicle Center Cell Lymphomas and Large B Cell Lymphomas of the Leg Descend from Germinal Center Cells. A Single Cell Polymerase Chain."— Presentation transcript:

1 Primary Cutaneous Follicle Center Cell Lymphomas and Large B Cell Lymphomas of the Leg Descend from Germinal Center Cells. A Single Cell Polymerase Chain Reaction Analysis  Sylke Gellrich, Sascha Rutz, Sven Golembowski, Claudia Jacobs, Malgorzata von Zimmermann, Pamela Lorenz, Heike Audring, Marcus Muche, Wolfram Sterry, Sigbert Jahn  Journal of Investigative Dermatology  Volume 117, Issue 6, Pages (December 2001) DOI: /j x x Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions

2 Figure 1 Clinical presentation of cutaneous B cell lymphoma patients chosen for single cell analysis. The typical clinical picture of patient IL with a large B cell lymphoma of the leg (A) and patient UK with a follicle center cell lymphoma localized at the head (B) are shown. Journal of Investigative Dermatology  , DOI: ( /j x x) Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions

3 Figure 2 Histology of cutaneous B cell lymphomas. (1) follicle center cell lymphoma localized at the head; (2) large B cell lymphoma. (A) HE stain; (B) CD20; (C) GIEMSA; (D) bcl-2. Scale bar: (A, B) 50 μm; (C, D) 200 μm. Journal of Investigative Dermatology  , DOI: ( /j x x) Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions

4 Figure 3 Amino acid sequences of the variable regions of immunoglobulin heavy chains expressed in PCBCL. Amino acid exchanges in comparison with the respective germline gene are indicated by bold letters. Replacement mutations underlaid in gray represent common exchanges found in more than one tumor patient. Identified D-gene segments are underlined. Sequences of identified subclones are named using capital letters after the number of the rearranged V gene family. Indication of the location of CDR and FR stretches, and position numbering are given. Journal of Investigative Dermatology  , DOI: ( /j x x) Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions

5 Figure 4 Amino acid sequences of the variable regions of immunoglobulin light chains expressed in PCBCL. Amino acid exchanges in comparison with the respective germline gene are indicated by bold letters. Replacement mutations underlaid in gray represent common exchanges found in more than one tumor patient. Sequences of identified subclones are named using capital letters after the number of the rearranged V gene family. Identified D-gene segments are underlined. Indication of the location of CDR and FR stretches, and position numbering are given. Journal of Investigative Dermatology  , DOI: ( /j x x) Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions

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