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Genetic Analysis of Meiotic Recombination in Humans by Use of Sperm Typing: Reduced Recombination within a Heterozygous Paracentric Inversion of Chromosome.

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Presentation on theme: "Genetic Analysis of Meiotic Recombination in Humans by Use of Sperm Typing: Reduced Recombination within a Heterozygous Paracentric Inversion of Chromosome."— Presentation transcript:

1 Genetic Analysis of Meiotic Recombination in Humans by Use of Sperm Typing: Reduced Recombination within a Heterozygous Paracentric Inversion of Chromosome 9q32-q34.3  Graeme M. Brown, Margaret Leversha, Maj Hulten, Malcolm A. Ferguson-Smith, Nabeel A. Affara, Robert A. Furlong  The American Journal of Human Genetics  Volume 62, Issue 6, Pages (June 1998) DOI: /301863 Copyright © 1998 The American Society of Human Genetics Terms and Conditions

2 Figure 1 Schematic diagram of six inv(9) recombinant sperm. Each locus is represented by a “0” or “1” indicating the chromosomal origin of the allele. Boxed loci are those within the inversion. Sperm a–f are discussed in the text. The American Journal of Human Genetics  , DOI: ( /301863) Copyright © 1998 The American Society of Human Genetics Terms and Conditions

3 Figure 2 Putative mechanism of recombination within the inverted region of inv(9). Only pairing chromatids are shown, with the inversion segment indicated. See text for a description. The American Journal of Human Genetics  , DOI: ( /301863) Copyright © 1998 The American Society of Human Genetics Terms and Conditions

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