1. Figure 1 Timeline of pancreatic islet transplantation
Figure 1 | Timeline of pancreatic islet transplantation. This timeline charts the progress of pancreatic islet transplantation, from the first description of pancreatic islets and the initial islet isolation and transplantation results in preclinical model systems, to the development of the 'automated method' for human islet isolation, the first successful cases of islet transplantation in patients with T1DM, the Edmonton protocol and the successful completion of the FDA phase III multicentre trial of islet transplantation for the most severe cases of T1DM complicated by severe hypoglycaemic episodes and hypoglycaemia unawareness. T1DM, type 1 diabetes mellitus. Modified with permission from Piemonti L, Pileggi A. 25 Years of the Ricordi Automated Method for Islet Isolation. CellR4 2013; 1 (1): e128 (Ref. 51).
Modified with permission from Piemonti L, Pileggi A. 25 Years
of the Ricordi Automated Method for Islet Isolation. CellR4 2013; 1 (1): e128 (REF. 51).
Shapiro, A. M. J. et al. (2016) Clinical pancreatic islet transplantation
Nat. Rev. Endocrinol. doi: /nrendo