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Meiotic Microdeletion Breakpoints in the BRCA1 Gene Are Significantly Associated with Symmetric DNA-Sequence Elements  Beatrice Schmucker, Michael Krawczak 

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Presentation on theme: "Meiotic Microdeletion Breakpoints in the BRCA1 Gene Are Significantly Associated with Symmetric DNA-Sequence Elements  Beatrice Schmucker, Michael Krawczak "— Presentation transcript:

1 Meiotic Microdeletion Breakpoints in the BRCA1 Gene Are Significantly Associated with Symmetric DNA-Sequence Elements  Beatrice Schmucker, Michael Krawczak  The American Journal of Human Genetics  Volume 61, Issue 6, Pages (December 1997) DOI: /301631 Copyright © 1997 The American Society of Human Genetics Terms and Conditions

2 Figure 1 Partial BRCA1 exon 11 sequence of a 3599/3600del11 carrier and of a control. The deletion junctions are indicated by arrows. Symmetric elements upstream of the proximal breakpoint are boxed. The mutation was detected in a male obligate carrier manifesting prostate cancer and in four first-degree female relatives with breast cancer. The American Journal of Human Genetics  , DOI: ( /301631) Copyright © 1997 The American Society of Human Genetics Terms and Conditions

3 Figure 2 Distribution of the minimum distance between a deletion breakpoint and a nearby symmetric element of a given length. Observed (blackened boxes) and expected (shaded boxes) frequencies of distance intervals are shown for element lengths of 5 (A), 6 (B), and 7 (C) nucleotides. The American Journal of Human Genetics  , DOI: ( /301631) Copyright © 1997 The American Society of Human Genetics Terms and Conditions

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