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Nick Barker, Alexander van Oudenaarden, Hans Clevers  Cell Stem Cell 

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Presentation on theme: "Nick Barker, Alexander van Oudenaarden, Hans Clevers  Cell Stem Cell "— Presentation transcript:

1 Identifying the Stem Cell of the Intestinal Crypt: Strategies and Pitfalls 
Nick Barker, Alexander van Oudenaarden, Hans Clevers  Cell Stem Cell  Volume 11, Issue 4, Pages (October 2012) DOI: /j.stem Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 The Stem Cells of the Small Intestine: A Historical Perspective Cell Stem Cell  , DOI: ( /j.stem ) Copyright © 2012 Elsevier Inc. Terms and Conditions

3 Figure 2 A Closer Look at the Human CBC Stem Cells
CBC stem cells (black arrows) are readily identifiable as slender cells with large basal nuclei and luminal microvilli. Note the intimate association with the Paneth cells (red arrows), which supply many of the niche factors. Cell Stem Cell  , DOI: ( /j.stem ) Copyright © 2012 Elsevier Inc. Terms and Conditions

4 Figure 3 Crypt Regeneration following Injury: Reserve Stem Cells versus Plasticity CBC stem cells rapidly die following acute injury such as irradiation. Crypt survival/regeneration may result from either reactivation of a quiescent Lgr5-ve (+4) stem cell population (upper panel) or from dedifferentiation of non-stem cells to generate new CBC stem cells (lower panel). Cell Stem Cell  , DOI: ( /j.stem ) Copyright © 2012 Elsevier Inc. Terms and Conditions

5 Figure 4 The +4 Stem Cells of the Small Intestine: A Current Perspective Cell Stem Cell  , DOI: ( /j.stem ) Copyright © 2012 Elsevier Inc. Terms and Conditions


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