1. Effects of venlafaxine, buspirone, and placebo on colonic sensorimotor functions in healthy humans 
Heather J. Chial, Michael Camilleri, Irene Ferber, Silvia Delgado-Aros, Duane Burton, Sanna McKinzie, Alan R. Zinsmeister 
Clinical Gastroenterology and Hepatology 
Volume 1, Issue 3, Pages (May 2003)
DOI: /S (03)70038-X
Copyright © 2003 American Gastroenterological Association Terms and Conditions

2. Fig. 1
Experimental protocol. Outline of the experimental protocol. ■, Assessment of colonic compliance, fasting tone, and sensation; ▩, assessment of postprandial colonic tone.
Clinical Gastroenterology and Hepatology 2003 1, DOI: ( /S (03)70038-X)
Copyright © 2003 American Gastroenterological Association Terms and Conditions

3. Fig. 2
Compliance curves (adjusted) showing median data. Note venlafaxine increases colonic compliance.
Clinical Gastroenterology and Hepatology 2003 1, DOI: ( /S (03)70038-X)
Copyright © 2003 American Gastroenterological Association Terms and Conditions

4. Fig. 3
Effects on fasting colonic tone. Note the significant increase in intracolonic balloon volume after drug administration for venlafaxine, suggesting it relaxes the colon. *Overall P < 0.01; P = for venlafaxine vs. placebo, unadjusted for 3 pairwise comparisons.
Clinical Gastroenterology and Hepatology 2003 1, DOI: ( /S (03)70038-X)
Copyright © 2003 American Gastroenterological Association Terms and Conditions

5. Fig. 4
Effects on postprandial colonic tone. *Overall P < 0.01; P = for venlafaxine vs. placebo, unadjusted for 3 pairwise comparisons.
Clinical Gastroenterology and Hepatology 2003 1, DOI: ( /S (03)70038-X)
Copyright © 2003 American Gastroenterological Association Terms and Conditions

6. Fig. 5
Effects on (A) first sensation and (B) first perception of gas. Overall P = 0.1 for first sensation. Overall P = 0.07 for first perception of gas.
Clinical Gastroenterology and Hepatology 2003 1, DOI: ( /S (03)70038-X)
Copyright © 2003 American Gastroenterological Association Terms and Conditions

7. Fig. 6
Overall effect on sensation scores for pain in response to increasing pressures. *Overall P = 0.02 for the linear trend over the 4 pressure levels.
Clinical Gastroenterology and Hepatology 2003 1, DOI: ( /S (03)70038-X)
Copyright © 2003 American Gastroenterological Association Terms and Conditions