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Fludarabine-Busulfan Reduced-Intensity Conditioning in Comparison with Fludarabine- Melphalan Is Associated with Increased Relapse Risk In Spite of Pharmacokinetic.

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Presentation on theme: "Fludarabine-Busulfan Reduced-Intensity Conditioning in Comparison with Fludarabine- Melphalan Is Associated with Increased Relapse Risk In Spite of Pharmacokinetic."— Presentation transcript:

1 Fludarabine-Busulfan Reduced-Intensity Conditioning in Comparison with Fludarabine- Melphalan Is Associated with Increased Relapse Risk In Spite of Pharmacokinetic Dosing  Moussab Damlaj, Hassan B. Alkhateeb, Mehrdad Hefazi, Daniel K. Partain, Shahrukh Hashmi, Dennis A. Gastineau, Aref Al-Kali, Robert C. Wolf, Naseema Gangat, Mark R. Litzow, William J. Hogan, Mrinal M. Patnaik  Biology of Blood and Marrow Transplantation  Volume 22, Issue 8, Pages (August 2016) DOI: /j.bbmt Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 (A) Platelet engraftment stratified by conditioning regimen. Plt indicates platelet. (B) ANC engraftment stratified by conditioning regimen. ANC indicates absolute neutrophil count. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 (A) Acute (a)GVHD grades II to IV stratified by conditioning regimen. (B) aGVHD grades III to IV stratified by conditioning regimen. (C) Chronic (c)GVHD stratified by conditioning regimen. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 (A) CIR stratified by conditioning regimen. (B) CI of NRM stratified by conditioning regimen. CI indicates cumulative incidence. (C) CI of NRM for patients with KPS < 90 stratified by conditioning regimen. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

5 Figure 4 (A) PFS stratified by conditioning regimen. (B) OS stratified by conditioning regimen. (C) OS for patients with KPS ≥ 90 stratified by conditioning regimen. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

6 Figure 5 CIR stratified by AUC level of first-dose Bu.
Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

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