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Infected Cells Call Their Killers to the Scene of the Crime

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Presentation on theme: "Infected Cells Call Their Killers to the Scene of the Crime"— Presentation transcript:

1 Infected Cells Call Their Killers to the Scene of the Crime
Lalit K. Beura, David Masopust  Immunity  Volume 42, Issue 3, Pages (March 2015) DOI: /j.immuni Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Hickman et al. Provide Evidence that Vaccinia-Infected Inflammatory Monocytes Attract Effector CD8+ T Cells within the Dermis This attraction depends on CXCR3-dependent CD8+ T cell chemotaxis toward CXCL9 and/or CXCL10 gradients produced by inflammatory monocytes upon infection, increasing the rapidity of viral control. Cxcr3−/− CD8+ T cells failed to follow this chemokine gradient (depicted by the wandering CD8+ T cell in the lower right). These data support a model by which virally infected hosts cells might contribute to their own immunosurveillance and elimination by CD8+ T cells. Immunity  , DOI: ( /j.immuni ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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