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Diarrhea during the Conditioning Regimen Is Correlated with the Occurrence of Severe Acute Graft-versus-Host Disease through Systemic Release of Inflammatory.

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Presentation on theme: "Diarrhea during the Conditioning Regimen Is Correlated with the Occurrence of Severe Acute Graft-versus-Host Disease through Systemic Release of Inflammatory."— Presentation transcript:

1 Diarrhea during the Conditioning Regimen Is Correlated with the Occurrence of Severe Acute Graft-versus-Host Disease through Systemic Release of Inflammatory Cytokines  Daihong Liu, Chenhua Yan, Lanping Xu, Yu Wang, Wei Han, Xiaohui Zhang, Kaiyan Liu, Xiaojun Huang  Biology of Blood and Marrow Transplantation  Volume 16, Issue 11, Pages (November 2010) DOI: /j.bbmt Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Cumulative incidence of aGVHD in 101 patients. Patients were divided into 3 groups according to the severity of diarrhea related to the conditioning regimen. If the patients developed diarrhea related to the conditioning regimen, and any 1 of the 3 risk factors was positive, the diarrhea was defined as severe diarrhea. in the absence of these criteria, the diarrhea was defined as mild diarrhea. 1∗ represents the P value in the patients with severe diarrhea compared with the patients without diarrhea; 2∗ represents the P value in the patients with severe diarrhea compared with the patients with mild diarrhea; 3∗ represents the P value in the patients with mild diarrhea compared with the patients without diarrhea. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Kinetic analyses showing that the serum levels of IL-6 and TNF-α are associated with the occurrence and severity of diarrhea related to the conditioning regimen. Fifty patients were divided into 3 groups according to the severity of diarrhea related to the conditioning regimen. If the patients developed diarrhea related to the conditioning regimen, and any 1 of the 3 risk factors was positive, the diarrhea was defined as severe diarrhea. Otherwise, the diarrhea was defined as mild diarrhea. 1∗ represents P < .05 in the patients with severe diarrhea compared with the patients without diarrhea; 2∗ represents P < .05 in the patients with severe diarrhea compared with the patients with mild diarrhea. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Kinetic analyses showing that the serum levels of IL-6 and TNF-α are associated with the occurrence of aGVHD of grade II to IV. (A, B) Fifty patients were divided into 2 groups according to the severity of aGVHD. (C–F) Fifty patients were divided into 3 groups according to the severity of diarrhea related to the conditioning regimen. If the patients developed diarrhea related to the conditioning regimen, and any 1 of the 3 risk factors was positive, the diarrhea was defined as severe diarrhea. Otherwise, the diarrhea was defined as mild diarrhea. 1∗ represents P < .05 in the patients with severe diarrhea compared with the patients without diarrhea; 2∗ represents P < .05 in the patients with severe diarrhea compared with the patients with mild diarrhea. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

5 Figure 4 OS and TRM in 101 patients. Patients were divided into 3 groups according to the severity of diarrhea related to the conditioning regimen. If the patients developed diarrhea related to the conditioning regimen, and any 1 of the 3 risk factors was positive, the diarrhea was defined as severe diarrhea. Otherwise, the diarrhea was defined as mild diarrhea. 1∗ represents the P value in the patients with severe diarrhea compared with the patients without diarrhea; 2∗ represents the P value in the patients with severe diarrhea compared with the patients with mild diarrhea; 3∗ represents the P value in the patients with mild diarrhea compared with the patients without diarrhea. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions


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